Multi-phasic nanoparticles

• US 7,767,017 B2
• Filed: 11/10/2005
• Issued: 08/03/2010
• Est. Priority Date: 11/10/2004
• Status: Expired due to Fees

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Rob, Kyung-Ho, Martin, David C., Lahann, Joerg
• Primary Examiner(s): Mayes; Melvin C
• Assistant Examiner(s): Qian; Yun
• Application Number:
  US11/272,194
• Publication Number:
  US 20060201390A1
• Time in Patent Office: 1,727 Days
• Field of Search: 106/401
• US Class Current: 106/401
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C08J 2371/12 Polyphenylene oxides
• CPC Class Codes: C08J 3/12 Powdering or granulating
• CPC Class Codes: C08J 3/20 Compounding polymers with additives, e.g. colouring
• CPC Class Codes: C08J 3/246 Intercrosslinking of at least two polymers
• CPC Class Codes: D01D 5/0069 characterised by the spinning section, e.g. capillary tube, protrusion or pin
• CPC Class Codes: D01D 5/32 Side-by-side structure; Spinnerette packs therefor
• CPC Class Codes: D01F 8/00 Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
• CPC Class Codes: Y10S 977/906 Drug delivery

Abstract

A method of forming multi-phasic nano-objects involves the jetting of two or more different liquids in side-by-side capillaries thereby generating a composite liquid stream. The composite then exposed to a force field which causes the composite liquid stream to at least partially solidify into a nano-object. The method forms a nano-object having a number of morphologies such as rods, spheres, and fibers.

Claims

1. A nano-object having at least one spatial dimension of about 5 nm to about 5000 nm comprising multiple chemically distinct exposed surface regions, wherein at least two of the multiple chemically distinct exposed surface regions independently comprise a polymeric material.

2. The nano-object of claim 1 wherein the nano-object is a biphasic nano-object.

3. The nano-object of claim 1 wherein the nano-object has a morphology selected from the group consisting of spheres, rods, fibers, and combinations thereof.

4. The nano-object of claim 1 wherein one or more of the multiple chemically distinct exposed surface regions comprises an additive.

5. The nano-object of claim 4 wherein the additive is selected from the group consisting of inorganic nanocrystals, quantum dots, biomolecules, colorants, crosslinkers, pharmaceutical compounds, molecular probes, and molecules that enable drug delivery.

6. The nano-object of claim 4 wherein the additive is a colorant.

7. The nano-object of claim 6, wherein the nano-object is a multiphase colorant.

8. The nano-object of claim 1, wherein at least two of the multiple chemically distinct exposed surface regions have different colors.

9. The nano-object of claim 1, wherein the nano-object is spherical.

10. The nano-object of claim 1, wherein the nano-object is non-spherical.

11. The nano-object of claim 1, wherein the nano-object comprises at least two phases.

12. The nano-object of claim 11, wherein at least two of the phases form a side-by-side morphology.

13. The nano-object of claim 11, wherein one or more of the phases includes one or more reactive components that react with a structural component thereby rendering a resulting surface of the nano-object chemically modified as compared to the surface when the one or more reactive components are not present.

14. The nano-object of claim 11, wherein at least one of the phases contains a drug.

15. The nano-object of claim 1, wherein the polymeric material is formed from a curable polymer precursor, a polymer solution, and/or a polymer melt.

16. The nano-object of claim 1, wherein the polymeric material comprises a polymer selected from the group consisting of:

polyethylene glycol, polycaprolactone, polyglycolic acid, and combinations thereof.

17. The nano-object of claim 1, wherein the polymeric material has been cured thermally or by exposure to actinic radiation.

18. The nano-object of claim 1, wherein the nano-object has a spatial dimension between about 20 nm and about 2000 nm.

19. The nano-object of claim 1, wherein the nano-object has a spatial dimension between about 50 nm and 500 nm.

20. The nano-object of claim 1, wherein at least one of the multiple chemically distinct surface regions contains a receptor.

21. The nano-object of claim 20, wherein at least one distinct surface of each particle contains a common receptor.

22. A nano-object having at least one spatial dimension of about 5 nm to about 5000 nm comprising at least two phases each independently comprising a polymeric material wherein the nano-object has at least two distinct exposed surface regions, wherein the nano-object has a morphology selected from the group consisting of spheres, rods, fibers and combinations thereof.

23. The nano-object of claim 22, wherein the nano-object is a biphasic nano-object.

24. The nano-object of claim 22, wherein the nano-object further comprises an additive.

25. The nano-object of claim 24, wherein the additive is selected from the group consisting of inorganic nanocrystals, quantum dots, biomolecules, colorants, crosslinkers, pharmaceutical compounds, molecular probes, and molecules that enable drug delivery.

26. The nano-object of claim 24, wherein the additive is a colorant.

27. The nano-object of claim 22, wherein at least two of the phases have different colors.

28. The nano-object of claim 22, wherein the nano-object has a spatial dimension between about 20 nm and about 2000 nm.

29. The nano-object of claim 22, wherein the nano-object has a spatial dimension between about 50 nm and 500 nm.

30. The nano-object of claim 22, wherein the nano-object is non-spherical.

31. The nano-object of claim 22, wherein the nano-object is spherical.

32. The nano-object of claim 22, wherein at least one of the multiple phases contains a drug.

33. The nano-object of claim 22, wherein at least one of the phases contains a receptor.

34. A nano-object having at least one spatial dimension of about 5 nm to about 5000 nm comprising at least two chemically distinct phases that form multiple chemically distinct exposed surfaces to define sides of the nano-object, wherein each of the at least two chemically distinct phases independently comprises a polymeric material.