Noninvasive vascular therapy
First Claim
1. A method for destroying or impairing target cells of a lesion in the vascular system in a mammalian subject, comprising:
- administering to the subject a therapeutically effective amount of a photosensitizing agent, wherein the photosensitizing agent is conjugated to a ligand that selectively binds to an antigen on the target cells of the lesion in the vascular system, wherein the ligand is an antibody or an antibody fragment specific to the antigen selected from the group consisting of tumor surface antigen;
tumor endothelial antigen;
non-tumor endothelial antigen;
tumor vessel wall antigen;
neointimal antigens;
arterial plaque antigens; and
vascular smooth muscle cell antigens; and
irradiating at least a portion of the subject with light at a wavelength absorbed by the photosensitizing agent, wherein;
the light is provided by a light source that is external to the intact body of the subject;
the irradiation is at a rate of between about 5 and 100mW/cm2 and results in the activation of the photosensitizing agent; and
the photosensitizing agent is cleared from the skin and subcutaneous tissues of the subject prior to the irradiation; and
wherein the duration of radiation exposure is between about 2 hours and 24 hours and the total light dose is between 500 J/cm2 and 10000 J/cm2.
6 Assignments
0 Petitions
Accused Products
Abstract
The present invention is drawn to methods and compounds for transcutaneous photodynamic therapy (“PDT”) of a target tissue or compositions in a mammalian subject, which includes administering to the subject a therapeutically effective amount of a photosensitizing agent or a photosensitizing agent delivery system or prodrug, where the photosensitizing agent or photosensitizing agent delivery system or prodrug selectively binds to the target tissue; and irradiating at least a portion of the subject with light at a wavelength absorbed by the photosensitizing agent or if prodrug, by a prodrug product thereof, where the light is provided by a light source, and where the irradiation is at low fluence rate that results in the activation of the photosensitizing agent or prodrug product. These methods of transcutaneous PDT are useful in the treatment of specifically selected target tissues, such as: vascular endothelial tissue; abnormal vascular wall of tumors; tumors of the head and neck; tumors of the gastrointestinal tract; tumors of the liver; tumors of the esophopharyngeal; tumors of the lung; lymphoid tissue; lesions in the vascular system; bone marrow and tissue related to autoimmune disease.
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Citations
18 Claims
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1. A method for destroying or impairing target cells of a lesion in the vascular system in a mammalian subject, comprising:
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administering to the subject a therapeutically effective amount of a photosensitizing agent, wherein the photosensitizing agent is conjugated to a ligand that selectively binds to an antigen on the target cells of the lesion in the vascular system, wherein the ligand is an antibody or an antibody fragment specific to the antigen selected from the group consisting of tumor surface antigen;
tumor endothelial antigen;
non-tumor endothelial antigen;
tumor vessel wall antigen;
neointimal antigens;
arterial plaque antigens; and
vascular smooth muscle cell antigens; andirradiating at least a portion of the subject with light at a wavelength absorbed by the photosensitizing agent, wherein; the light is provided by a light source that is external to the intact body of the subject; the irradiation is at a rate of between about 5 and 100mW/cm2 and results in the activation of the photosensitizing agent; and the photosensitizing agent is cleared from the skin and subcutaneous tissues of the subject prior to the irradiation; and
wherein the duration of radiation exposure is between about 2 hours and 24 hours and the total light dose is between 500 J/cm2 and 10000 J/cm2. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 15, 16, 18)
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2. A method for destroying or impairing target cells of a lesion in the arterial vascular system in a mammalian subject, comprising:
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administering to the subject a therapeutically effective amount of a first conjugate comprising a first member of a ligand-receptor binding pair conjugated to an antibody or antibody fragment, wherein the antibody or antibody fragment selectively binds to an antigen on the target cells of the lesion in the arterial vascular system, wherein said antigen selected from the group consisting of tumor surface antigen;
tumor endothelial antigen;
non-tumor endothelial antigen;
tumor vessel wall antigen;
neointimal antigens;
arterial plaque antigens; and
vascular smooth muscle cell antigens;administering to the subject a therapeutically effective amount of a second conjugate comprising a second member of the ligand-receptor binding pair conjugated to a photosensitizing agent or photosensitizing agent delivery system, wherein the first member binds to the second member of the ligand-receptor binding pair; and irradiating at least a portion of the subject with light at a wavelength absorbed by the photosensitizing agent, wherein the light is provided by a light source that is external to the subject, wherein the irradiation is between about 5 and 100 mW/cm2 and that results in the activation of the photosensitizing agent or prodrug product; and
wherein the duration of radiation exposure is between about 2 hours and 24 hours and the total light dose is between 500 J/cm2 and 10000 J/cm2. - View Dependent Claims (14, 17)
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Specification