Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone
First Claim
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1. A scaffold apparatus for musculoskeletal tissue engineering, said apparatus comprising microspheres of selected sizes and/or concentrations, wherein the microspheres are layered to have a gradient of microsphere sizes and/or concentrations, and wherein the scaffold promotes growth and maintenance of a soft tissue and bone.
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Abstract
Methods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The microspheres are layered to have a gradient of microsphere sizes and/or compositions. The scaffold provides a functional interface between multiple tissue types.
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Citations
60 Claims
- 1. A scaffold apparatus for musculoskeletal tissue engineering, said apparatus comprising microspheres of selected sizes and/or concentrations, wherein the microspheres are layered to have a gradient of microsphere sizes and/or concentrations, and wherein the scaffold promotes growth and maintenance of a soft tissue and bone.
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56. A multi-phased scaffold apparatus for providing a functional interface between bone and soft tissue, comprising:
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microspheres as one phase of the scaffold; and a mesh as another phase of the scaffold, wherein the microspheres and the mesh are sintered or solvent casted together and wherein the microspheres are layered to have a gradient of microsphere sizes and/or compositions. - View Dependent Claims (57, 58)
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59. A scaffold apparatus for musculoskeletal tissue engineering, said apparatus comprising microspheres of selected sizes, wherein the microspheres are layered to have a gradient of microsphere sizes, and wherein the scaffold promotes growth and maintenance of a soft tissue, bone and fibrocartilage.
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60. A scaffold apparatus for musculoskeletal tissue engineering, said apparatus comprising microspheres of selected concentrations, wherein the microspheres are layered to have a gradient of microsphere concentrations, and wherein the scaffold promotes growth and maintenance of a soft tissue, bone and fibrocartilage.
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