Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use
First Claim
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1. An intraocular, bioerodible drug delivery system comprising a steroid effective in preventing or reducing neovascularization in an eye prone to neovascularization, and a bioerodible polymer selected from the group consisting of hydroxyaliphatic carboxylic acids, and polysaccharides, thereby forming an implant for placement in the interior of an eye prone to neovascularization, wherein:
- (a) the steroid is dexamethasone and comprises about 50% to 80% of the weight of the drug delivery system;
(b) the drug delivery system is configured for placement in the vitreous, wherein the system is effective in releasing the dexamethasone into the eye over a period of at least about 8 weeks.
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Abstract
Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
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Citations
26 Claims
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1. An intraocular, bioerodible drug delivery system comprising a steroid effective in preventing or reducing neovascularization in an eye prone to neovascularization, and a bioerodible polymer selected from the group consisting of hydroxyaliphatic carboxylic acids, and polysaccharides, thereby forming an implant for placement in the interior of an eye prone to neovascularization, wherein:
- (a) the steroid is dexamethasone and comprises about 50% to 80% of the weight of the drug delivery system;
(b) the drug delivery system is configured for placement in the vitreous, wherein the system is effective in releasing the dexamethasone into the eye over a period of at least about 8 weeks. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- (a) the steroid is dexamethasone and comprises about 50% to 80% of the weight of the drug delivery system;
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11. An intraocular, bioerodible drug delivery system comprising particles of dexamethasone and a polylactic acid polyglycolic acid (PLGA) copolymer, wherein the system is effective in releasing the dexamethasone into the eye over a period of at least about 5 days, and wherein the intraocular, bioerodible drug delivery system is a single pellet or a single extruded filament, and wherein:
- (a) the dexamethasone comprises about 50% to 80% of the weight of the drug delivery system; and
(b) the drug delivery system is configured for placement in the vitreous, wherein the system is effective in releasing the dexamethasone into the eye over a period of at least about 8 weeks. - View Dependent Claims (12, 13, 14, 15, 16)
- (a) the dexamethasone comprises about 50% to 80% of the weight of the drug delivery system; and
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17. An intraocular, bioerodible drug delivery system comprising a drug effective in preventing or reducing edema in an eye prone to edema, and a bioerodible polymer, wherein:
- (a) the drug is dexamethasone and comprises about 50% to 80% of the weight of the drug delivery system; and
(b) the drug delivery system is configured for placement in the vitreous, wherein the system is effective in releasing the dexamethasone into the eye over a period of at least about 8 weeks. - View Dependent Claims (18)
- (a) the drug is dexamethasone and comprises about 50% to 80% of the weight of the drug delivery system; and
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19. An intraocular, bioerodible drug delivery system comprising a steroid effective in preventing or reducing neovascularization in an eye prone to neovascularization, and a bioerodible polymer selected from the group consisting of hydroxyaliphatic carboxylic acids, and polysaccharides, thereby forming an implant for placement in the interior of an eye prone to neovascularization, wherein:
- (a) the steroid is dexamethasone and comprises about 50% to 80% of the weight of the drug delivery system;
(b) the drug delivery system is configured for placement in the vitreous, and;
(c) the drug delivery system is effective in releasing the drug into the eye over a period of at least about 8 weeks. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
- (a) the steroid is dexamethasone and comprises about 50% to 80% of the weight of the drug delivery system;
Specification