Bioassay system including optical detection apparatuses, and method for detecting biomolecules
DC CAFCFirst Claim
1. An apparatus for identifying a single biomolecule, comprising:
- a substrate having a light detector; and
a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site;
wherein the linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers.
3 Assignments
Litigations
2 Petitions
Accused Products
Abstract
A bioassay system is disclosed. The bioassay system may include a plurality of optical detection apparatuses, each of which includes a substrate having a light detector, and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site. The linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. The light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian. The optical detection apparatus may further include an excitation light source formed over the substrate so as to provide a light source for exciting a fluorophore attached to the biomolecule.
-
Citations
58 Claims
-
1. An apparatus for identifying a single biomolecule, comprising:
-
a substrate having a light detector; and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site; wherein the linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
-
-
48. An apparatus for identifying a single biomolecule, comprising:
-
a substrate having a light detector; a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site; and an excitation light source formed over the substrate; wherein the linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. - View Dependent Claims (49, 50, 51, 52)
-
-
53. An apparatus for identifying a single biomolecule, comprising:
-
a substrate having a light detector; and a linker site formed over the light detector, the linker site being treated to affix the biomolecule to the linker site; wherein the light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian.
-
-
54. An apparatus for identifying a single biomolecule, comprising:
-
a substrate having a light detector; a linker site formed over the light detector, the linker site being treated to affix the biomolecule to it; and an excitation light source formed over the substrate; wherein the light detector collects light emitted from the biomolecule within a solid angle of greater than or equal to 0.8 SI steridian.
-
-
55. A method for manufacturing an apparatus for identifying a single biomolecule, comprising:
-
forming a light detector and a control circuit on a substrate; forming a blind sheet having a pinhole over the substrate; and forming a linker site over the light detector and proximate to the pinhole, the linker site being treated to affix the biomolecule to the linker site, wherein the linker site is proximate to the light detector and is spaced apart from the light detector by a distance of less than or equal to 100 micrometers. - View Dependent Claims (56, 57, 58)
-
Specification