Blends of temperature sensitive and anionic polymers for drug delivery
First Claim
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1. A solid gel injectable polymer matrix comprising:
- (a) methylcellulose having a molecular weight between 2,000 Da and 1,000,000 Da, and,(b) hyaluronic acid having a molecular weight between 100,000 Da and 7,000,000 Da;
the polymer matrix comprising a solid gel prior to injection, undergoing shear thinning upon injection, and returning to a solid gel after injection,wherein the ratio of the methylcellulose to the hyaluronic acid is at least 1;
1 to 20;
1 w/w, andwherein the amounts of (a) and (b) are selected to obtain said solid gel.
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Abstract
A physical blend of inverse thermal gelling and shear-thinning, thixotropic polymers that has a lower gelation temperature than the thermal gelling polymer alone is provided. The blend results in an injectable hydrogel that does not flow freely at room temperature, but is injectable due to its shear-thinning properties. The thermal-gelling properties of the polymer promote a more mechanically stable gel at body temperature than at room temperature. The polymer matrix gel has inherent therapeutic benefit and can also be used as a drug delivery vehicle for localized release of therapeutic agents.
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Citations
31 Claims
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1. A solid gel injectable polymer matrix comprising:
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(a) methylcellulose having a molecular weight between 2,000 Da and 1,000,000 Da, and, (b) hyaluronic acid having a molecular weight between 100,000 Da and 7,000,000 Da; the polymer matrix comprising a solid gel prior to injection, undergoing shear thinning upon injection, and returning to a solid gel after injection, wherein the ratio of the methylcellulose to the hyaluronic acid is at least 1;
1 to 20;
1 w/w, andwherein the amounts of (a) and (b) are selected to obtain said solid gel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 27, 28, 29, 30, 31)
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12. A solid gel injectable polymer matrix pharmaceutical delivery vehicle comprising:
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(a) methylcellulose having a molecular weight between 2,000 Da and 1,000,000 Da; (b) hyaluronic acid having a molecular weight between 100,000 Da and 7,000,000 Da; and
,(c) a pharmaceutical agent; the polymer matrix comprising a solid gel prior to injection, undergoing shear thinning upon injection, and returning to a solid gel after injection, wherein the ratio of the methylcellulose to the hyaluronic acid is at least 1;
1 to 20;
1 w/w, andwherein the amounts of (a) and (b) are selected to obtain said solid gel, for use as a carrier for said pharmaceutical agent. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification