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Blends of temperature sensitive and anionic polymers for drug delivery

  • US 7,767,656 B2
  • Filed: 04/25/2006
  • Issued: 08/03/2010
  • Est. Priority Date: 04/25/2005
  • Status: Active Grant
First Claim
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1. A solid gel injectable polymer matrix comprising:

  • (a) methylcellulose having a molecular weight between 2,000 Da and 1,000,000 Da, and,(b) hyaluronic acid having a molecular weight between 100,000 Da and 7,000,000 Da;

    the polymer matrix comprising a solid gel prior to injection, undergoing shear thinning upon injection, and returning to a solid gel after injection,wherein the ratio of the methylcellulose to the hyaluronic acid is at least 1;

    1 to 20;

    1 w/w, andwherein the amounts of (a) and (b) are selected to obtain said solid gel.

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