Optoelectronic biochip
First Claim
1. A monolithically integrated biochip for testing biological substances comprising a plurality of binding sites, optical means for determining a specific binding event at each binding site, wherein the plurality of binding sites are monolithically integrated by processing one substrate with the optical means for determining a specific binding event which comprise at least one microcavity light source, at least one photodetector and at least one planar waveguide, an evanescent field of light propagating in the waveguide interacting with the biological substance under test, and wherein the microcavity light source is a photonic band gap microcavity light source.
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Abstract
The present invention provides a biochip for testing biological substances comprising a plurality of binding sites, optical means for determining a specific binding event at each binding site, wherein the plurality of binding sites and the means for determining a specific binding event at each binding site are monolithically integrated into a single chip which is electrically powered and produces electrical signals in response to binding events at each binding site. The means for determining a specific binding event can include a micro-cavity light source formed in a semiconductor layer and a photodetector formed in the same semiconductor layer and further include a grating assisted vertical planar waveguide coupler for in-situ monitoring hybridization dynamics at each binding site via associated changes in refractive index. The invention further provides a method of manufacturing a biochip containing light sources, photodetectors, binding sites and optical means for determining a specific binding event at each binding site wherein said light sources, photodetectors, binding sites and optical means for determining a specific binding event at each binding site are produced by processing a single planar substrate in a sequence of deposition, photolithography and etching steps.
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Citations
12 Claims
- 1. A monolithically integrated biochip for testing biological substances comprising a plurality of binding sites, optical means for determining a specific binding event at each binding site, wherein the plurality of binding sites are monolithically integrated by processing one substrate with the optical means for determining a specific binding event which comprise at least one microcavity light source, at least one photodetector and at least one planar waveguide, an evanescent field of light propagating in the waveguide interacting with the biological substance under test, and wherein the microcavity light source is a photonic band gap microcavity light source.
Specification