MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting
First Claim
Patent Images
1. A method of predicting efficacy of a treatment in a subject, the method comprising:
- administering to a subject a liposome composition comprising;
(i) a contrast agent;
(ii) a compound of interest; and
(iii) a liposome encapsulating the contrast agent and the compound of interest;
monitoring accumulation of the compound of interest at a desired site in vivo by magnetic resonance imaging, wherein the monitoring comprises monitoring release of the contents of the liposome at the desired site by monitoring an increase in the presence of the contrast agent released from the liposome at the desired site as the contents of the liposome are being released at the desired site; and
predicting efficacy of treatment based on accumulation of the compound of interest at the desired site.
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Abstract
Methods and compositions useful for detecting an in vivo blood pool, monitoring the distribution of a compound of interest to a desired site in an organism by magnetic resonance imaging, monitoring the accumulation of a compound of interest at a desired site in vivo by magnetic resonance imaging, and monitoring the release of liposomal contents to an external stimulus at a desired site in vivo by magnetic resonance imaging are disclosed. Some compositions comprise envirosensitive or non-sensitive liposomes. Contrast agents, such as manganese-based compounds, are also disclosed.
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Citations
54 Claims
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1. A method of predicting efficacy of a treatment in a subject, the method comprising:
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administering to a subject a liposome composition comprising; (i) a contrast agent; (ii) a compound of interest; and (iii) a liposome encapsulating the contrast agent and the compound of interest; monitoring accumulation of the compound of interest at a desired site in vivo by magnetic resonance imaging, wherein the monitoring comprises monitoring release of the contents of the liposome at the desired site by monitoring an increase in the presence of the contrast agent released from the liposome at the desired site as the contents of the liposome are being released at the desired site; and predicting efficacy of treatment based on accumulation of the compound of interest at the desired site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 48, 49, 50)
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15. A method of enhancing efficacy of a treatment at a desired site in a subject, the method comprising:
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administering to the subject a composition comprising; (i) a contrast agent; (ii) a compound of interest; and (iii) a liposome encapsulating the contrast agent and the compound of interest; and controlling the distribution of the compound of interest at a desired site by targeting the composition to a desired location within or proximate to the desired site in the subject, at a desired rate of accumulation at the desired site, or both a desired location and desired rate of accumulation at the desired site, to thereby enhance efficacy of treatment provided by the compound of interest, wherein controlling the distribution comprises monitoring accumulation of the compound of interest at a desired site, wherein monitoring comprises monitoring release of the contents of the liposome at the desired site by monitoring an increase in the presence of the contrast agent released from the liposome at the desired site as the contents of the liposome are being released at the desired site. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 51, 52)
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32. A method of targeting delivery of a compound of interest at a desired site in vivo, the method comprising:
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administering to a subject a composition comprising; (i) a contrast agent; (ii) a compound of interest; and (iii) a liposome encapsulating the contrast agent and the compound of interest, wherein a non-physiological environmental condition is present at the desired site, targeting the delivery of the compound of interest to a desired location within or proximate to the desired site in the subject, at a desired rate of accumulation at the desired site, or both a desired location and desired rate of accumulation at the desired site by the presence of the non-physiological environmental condition, and monitoring accumulation of the compound of interest at a desired site, wherein monitoring comprises monitoring release of the contents of the liposome at the desired site by monitoring an increase in the presence of the contrast agent released from the liposome at the desired site as the contents of the liposome are being released at the desired site. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 53, 54)
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Specification