Method of physiological data analysis and measurement quality check using principal component analysis
First Claim
1. A computer-implemented method of analyzing patient physiological data collected as part of a pharmacological study, comprising a non-transitory computer-readable medium programmed with computer readable code, such that when a computer processor executes the computer readable code, the processor performs the steps of:
- receiving patient physiological data;
normalizing the patient physiological data;
performing a principal component analysis of the normalized patient physiological data;
comparing the principal component analysis of the normalized patient physiological data to a model patient physiological data principal component analysis, wherein the model physiological data principal component analysis is representative of a specific physiological morphological feature;
using the comparison to identify if the specific physiological morphological feature is present in the patient physiological data.
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Abstract
In a method of analyzing patient physiological data, the data is subjected to principal component analysis and compared to a model physiological data principal component analysis. The comparison is used to identify correlations present in the morphology of the patient physiological data. The present invention further includes determining a confidence interval for the detection of a morphological feature and utilizing this confidence interval for improving the quality of the detection of morphological features of the patient physiological data, including automated morphological feature identification.
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Citations
20 Claims
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1. A computer-implemented method of analyzing patient physiological data collected as part of a pharmacological study, comprising a non-transitory computer-readable medium programmed with computer readable code, such that when a computer processor executes the computer readable code, the processor performs the steps of:
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receiving patient physiological data; normalizing the patient physiological data; performing a principal component analysis of the normalized patient physiological data; comparing the principal component analysis of the normalized patient physiological data to a model patient physiological data principal component analysis, wherein the model physiological data principal component analysis is representative of a specific physiological morphological feature; using the comparison to identify if the specific physiological morphological feature is present in the patient physiological data. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of analyzing an ECG signal collected as part of a pharmacological drug trial, the method comprising the steps of:
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collecting ECG signal data; performing principal component analysis on the collected data; identifying characteristics of the ECG signal data by comparing the principal component analysis of the ECG signal data to a plurality of model principal component analysis, each of a specific morphological feature; sorting the ECG signal data into groups based upon the identified characteristics; performing a statistical analysis on the ECG signal data groups to determine an indication of ECG signal data group quality; using the ECG signal data group and the indication of ECG signal data group quality to derive a morphological detection algorithm. - View Dependent Claims (16, 17, 18, 19)
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20. A computer program embodied on a non-transitory computer-readable medium having computer logic for enabling at least one processor in a computer system to facilitate analyzing an ECG signal collected as part of a pharmacological drug trial, the non-transitory computer-readable medium comprising:
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a first computer readable program code portion for collecting ECG signal data; a second computer readable program code portion that perform a principal component analysis (PCA) of the collected ECG signal data to obtain a collected ECG signal data PCA, comparing the collected ECG signal data PCA to a plurality of model morphological feature PCA, and sorts the collected ECG signal data into groups based upon to which of the plurality of model morphological feature PCA the collected ECG signal data PCA is the most similar; a third computer readable program code portion creating a model of the ECG signal data in each of the groups; and a fourth computer readable program code portion using the model to detect a morphological feature of a future ECG signal.
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Specification