Cardiac neuromodulation and methods of using same

• US 7,769,441 B2
• Filed: 11/03/2005
• Issued: 08/03/2010
• Est. Priority Date: 04/20/2001
• Status: Active Grant

• Current Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Original Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Inventors: Armour, John A., Linderoth, Bengt G. S., DeJongste, Michael J. L., Ardell, Jeffrey L., Foreman, Robert D.
• Primary Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US11/266,558
• Publication Number:
  US 20060111745A1
• Time in Patent Office: 1,734 Days
• Field of Search: 607/9, 607/14, 607/2
• US Class Current: 607/2
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension

Abstract

The present invention relates in general to methodologies for the treatment quenching preconditioning and communication between the intrinsic cardiac nervous system and an electrical stimulus. In particular, the present invention utilizes spinal cord stimulation to alter and/or affect the intrinsic cardiac nervous system and thereby protect the myocytes, stabilize myocardial electrical instability and/or alleviate or diminish cardiac pathologies.

Claims

1. A method of providing cardioprotection:

identifying a subject susceptible to or suffering from a cardiac pathology;

implanting a stimulation device into the identified patient to electrically stimulate the spinal cord, wherein the stimulation device comprises a plurality of electrodes and a generator in which at least one electrode is placed near the spinal cord;

activating the stimulation device to deliver electrical stimulation to the spinal cord, wherein electrical stimulation of the spinal cord stabilizes adrenergic neurons thereby providing cardioprotection.

2. The method of claim 1, wherein the electrical stimulation stabilizes cardiomyocytes.

3. The method of claim 1, wherein the electrical stimulation alters catecholamine release.

4. The method of claim 1, wherein the electrical stimulation stabilizes the electrical activity of the heart.

5. The method of claim 1, wherein the electrical stimulation stabilizes the mechanical activity of the heart.

6. The method of claim 1, wherein the electrical stimulation reduces deleterious cardiac remodeling.

7. The method of claim 1, wherein the electrical stimulation stabilizes the activity of the autonomic nervous system.

8. The method of claim 1, wherein the cardiac pathology comprises arrhythmias.

9. The method of claim 8, wherein the arrhythmias are ventricular arrhythmias.

10. The method of claim 1, wherein the cardiac pathology is myocardial ischemia.

11. A method of decreasing cardiac remodeling due to a cardiac pathology:

identifying a patient suffering from or is susceptible to having the cardiac pathology;

implanting a stimulation device into the patient to electrically stimulate the spinal cord, wherein the stimulation device comprises a plurality of electrodes and a generator in which at least one electrode is placed near the spinal cord;

activating the stimulation device to deliver electrical stimulation to the spinal cord to suppress intrinsic cardiac nerve activity thereby decreasing cardiac remodeling due to the cardiac pathology.

12. The method of claim 11, wherein the electrical stimulation stabilizes cardiomyocytes.

13. The method of claim 11, wherein the electrical stimulation alters catecholamine release.

14. The method of claim 11, wherein the electrical stimulation stabilizes the electrical activity of the heart.

15. The method of claim 11, wherein the electrical stimulation stabilizes the mechanical activity of the heart.

16. The method of claim 11, wherein the electrical stimulation stabilizes the activity of the autonomic nervous system.

17. The method of claim 11, wherein the cardiac pathology is a myocardial ischemia.

18. A method of improving imbalance of activity of the autonomic nervous activity comprising:

identifying a patient suffering from or is susceptible to having an imbalance of activity of the autonomic nervous system;

implanting a stimulation device into the patient to electrically stimulate the spinal cord, wherein the stimulation device comprises a plurality of electrodes and a generator in which at least one electrode is placed near the spinal cord;

activating the stimulation device to deliver electrical stimulation to the spinal cord to suppress intrinsic cardiac nerve activity thereby improving imbalance of activity of the autonomic nervous system.