Device and method for inhibiting release of pro-inflammatory mediator
First Claim
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1. A method for inhibiting release of a proinflammatory mediator from a mammalian cell, the method comprising:
- identifying a mammalian subject suffering from, or at risk for, a disease or disorder mediated by a proinflammatory mediator; and
applying a stimulation signal to the subject in an amount effective to inhibit the release of the proinflammatory mediator, wherein the stimulation signal is directly applied to a splenic nerve, a splenic neurovascular bundle, a periarterial splenic nerve, splenic peritoneum, splenic tissue, celiac plexus surrounding a celiac artery, a celiac ganglion, an aorticorenal ganglion, a greater thoracic splanchnic nerve, a lesser thoracic splanchnic nerve, a least thoracic splanchinc nerve or a combination thereof.
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Abstract
Stimulation of one or more neurons of the sympathetic nervous system, including the splenic nerve, is provided to attenuate an immune response, including an inflammatory immune response. Devices such as pulse generators and drug pumps may be used to stimulate the sympathetic nervous system to attenuate an immune response. Systems optionally having one or more sensors and operator instructions may also be used. In specific examples, stimulation of the splenic nerve of pigs with a pulse generator is shown to be safe and effective in attenuating a lipopolysaccharide-induced immune response.
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Citations
20 Claims
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1. A method for inhibiting release of a proinflammatory mediator from a mammalian cell, the method comprising:
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identifying a mammalian subject suffering from, or at risk for, a disease or disorder mediated by a proinflammatory mediator; and applying a stimulation signal to the subject in an amount effective to inhibit the release of the proinflammatory mediator, wherein the stimulation signal is directly applied to a splenic nerve, a splenic neurovascular bundle, a periarterial splenic nerve, splenic peritoneum, splenic tissue, celiac plexus surrounding a celiac artery, a celiac ganglion, an aorticorenal ganglion, a greater thoracic splanchnic nerve, a lesser thoracic splanchnic nerve, a least thoracic splanchinc nerve or a combination thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification