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Device and method for inhibiting release of pro-inflammatory mediator

  • US 7,769,442 B2
  • Filed: 08/29/2006
  • Issued: 08/03/2010
  • Est. Priority Date: 10/01/2003
  • Status: Active Grant
First Claim
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1. A method for inhibiting release of a proinflammatory mediator from a mammalian cell, the method comprising:

  • identifying a mammalian subject suffering from, or at risk for, a disease or disorder mediated by a proinflammatory mediator; and

    applying a stimulation signal to the subject in an amount effective to inhibit the release of the proinflammatory mediator, wherein the stimulation signal is directly applied to a splenic nerve, a splenic neurovascular bundle, a periarterial splenic nerve, splenic peritoneum, splenic tissue, celiac plexus surrounding a celiac artery, a celiac ganglion, an aorticorenal ganglion, a greater thoracic splanchnic nerve, a lesser thoracic splanchnic nerve, a least thoracic splanchinc nerve or a combination thereof.

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