Cardiac rhythm management device with neural sensor

• US 7,769,450 B2
• Filed: 11/18/2004
• Issued: 08/03/2010
• Est. Priority Date: 11/18/2004
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Moffitt, Julia, Kramer, Andrew P., Libbus, Imad
• Primary Examiner(s): Getzow; Scott M
• Assistant Examiner(s): KAHELIN, MICHAEL WILLIAM
• Application Number:
  US10/992,320
• Publication Number:
  US 20060106428A1
• Time in Patent Office: 2,084 Days
• Field of Search: 607/17, 607/22, 607/23
• US Class Current: 607/17
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

Various aspects of the present subject matter relate to a device. In various embodiments, the device comprises at least one port adapted to connect at least one lead, a CRM functions module connected to the port and adapted to provide at least one CRM function using the lead, a neural function module, and a controller connected to the CRM functions module and the neural function module. The at least one CRM function includes a function to provide an electrical signal to the lead to capture cardiac tissue. The neural function module includes a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the lead into a signal indicative of the nerve traffic. The controller is adapted to implement a CRM therapy based on the signal indicative of the nerve traffic. Other aspects are provided herein.

Claims

1. A device, comprising:

at least one port adapted to connect at least one lead;

a cardiac rhythm management (CRM) functions module connected to the port and adapted to provide at least one CRM function using the at least one lead, the at least one CRM function including a function to provide an electrical signal to the lead to capture cardiac tissue;

a neural function module, including a signal processing module connected to the port and adapted to receive and process a nerve traffic signal from the at least one lead into a signal indicative of the nerve traffic; and

a controller connected to the CRM functions module and the neural function module, the controller being adapted to control the CRM function to provide a baseline response of a physiologic system to the CRM function, and to implement a procedure to receive feedback for use in controlling the CRM function, wherein the procedure implemented by the controller to receive feedback includes controlling the CRM function module to perturb the physiologic system from the baseline response to cause a transient nerve traffic response to the perturbed system, and determining the transient nerve traffic response to perturbing the physiologic system, the controller being adapted to implement the CRM function using the signal indicative of the transient nerve traffic response to perturbing the physiologic system as feedback for the CRM function.

2. The device of claim 1, wherein the signal indicative of the nerve traffic includes a signal indicative of a nerve traffic pattern.

3. The device of claim 1, wherein the signal indicative of the nerve traffic includes a signal indicative of nerve traffic intensity.

4. The device of claim 1, wherein the signal indicative of the nerve traffic includes a signal indicative of a nerve traffic pattern and nerve traffic intensity.

5. The device of claim 1, wherein signal processing module is adapted to implement a noise reduction algorithm to identify features of the nerve traffic signal.

6. The device of claim 5, wherein the noise reduction algorithm includes a wavelet transformation.

7. The device of claim 5, wherein the noise reduction algorithm identifies a pattern and an intensity of the nerve traffic signal.

8. The device of claim 1, wherein the signal processing module includes an amplifier and a filter adapted to process and monitor nerve traffic.

9. The device of claim 8, wherein the amplifier includes an amplifier with a gain of approximately 1,000 to approximately 99,000.

10. The device of claim 8, wherein the filter includes a bandpass filter to pass frequencies in a range from approximately 30 Hz to approximately 3,000 Hz.

11. The device of claim 1, wherein the signal indicative of nerve traffic includes a signal indicative of nerve traffic from a chemoreceptor that is indicative of a blood gas concentration.

12. The device of claim 1, wherein the signal indicative of nerve traffic includes a signal indicative of nerve traffic from at least one afferent nerve that is indicative of a blood gas concentration.

13. The device of claim 1, wherein the signal indicative of nerve traffic includes a signal indicative of nerve traffic from a baroreceptor that is indicative of blood pressure.

14. The device of claim 1, wherein the signal indicative of nerve traffic includes a signal indicative of nerve traffic from at least one afferent nerve that is indicative of blood pressure.

15. The device of claim 1, wherein the controller is adapted to adjust a CRM function parameter and monitor an effect on the signal indicative of nerve traffic, and to implement the CRM function based on the effect in the signal indicative of nerve traffic.

16. The device of claim 1, wherein the neural function module is adapted to detect mean sympathetic nerve activity changes, and the signal indicative of the nerve traffic is indicative of the mean sympathetic nerve activity changes.

17. The device of claim 1, wherein the neural function module is adapted to detect integrated sympathetic nerve activity changes, and the signal indicative of the nerve traffic is indicative of the integrated sympathetic nerve activity changes.

18. The device of claim 1, wherein the transient nerve traffic response has a duration less than 100 ms after the physiologic system is perturbed.

19. A system, comprising:

means for applying a cardiac rhythm management (CRM) therapy, wherein the CRM therapy is adapted to electrically capture cardiac tissue to provide a baseline response of a physiologic system to the CRM therapy;

means for receiving feedback for use in controlling the CRM therapy, wherein the means for receiving feedback includes;

means for perturbing the physiologic system from the baseline response to cause a transient nerve traffic response in preparation to sense a nerve traffic signal to determine the transient nerve traffic response;

means for sensing the nerve traffic signal to determine the transient nerve traffic response to perturbing the physiologic system; and

means for identifying at least one feature of the nerve traffic signal indicative of the transient nerve traffic response to perturbing the physiologic system; and

means for using the at least one feature of the nerve traffic signal indicative of the transient nerve traffic response as feedback for the CRM therapy.

20. The system of claim 19, wherein the means for identifying at least one feature of the nerve traffic signal includes means for implementing a noise reduction algorithm to identify the at least one feature of the nerve traffic signal.

21. The system of claim 19, wherein the noise reduction algorithm includes a wavelet transformation.

22. The system of claim 19, wherein the means for sensing a nerve traffic signal includes means for sensing a nerve traffic signal from a chemoreceptor, the nerve traffic signal being indicative of a blood gas concentration.

23. The system of claim 19, wherein the means for sensing a nerve traffic signal includes means for sensing a nerve traffic signal from at least one afferent nerve with nerve traffic indicative of a blood gas concentration.

24. The system of claim 19, wherein the means for sensing a nerve traffic signal includes means for sensing a nerve traffic signal from a baroreceptor, the nerve traffic signal being indicative of a blood pressure.

25. The system of claim 19, wherein the means for sensing a nerve traffic signal includes means for sensing a nerve traffic signal from at least one afferent nerve with nerve traffic indicative of a blood pressure.

26. The system of claim 19, wherein the means for sensing a nerve traffic signal includes an intravascular lead.

27. The system of claim 19, wherein the means for sensing a nerve traffic signal includes a nerve cuff.

28. The system of claim 19, wherein the means for perturbing the physiologic system includes:

means for changing a parameter for a cardiac rhythm management therapy to perturb the physiologic system;

means for applying a neural stimulation burst to perturb the physiologic system;

or

means for applying a premature myocardial stimulus to perturb the physiologic system.

29. The system of claim 19, wherein the transient nerve traffic response has a duration less than 100 ms after the physiologic system is perturbed.

39. The method of claim 25, wherein sensing a nerve traffic signal includes amplifying the nerve traffic signal to provide a gain within a range of approximately 1,000 to 99,000.

30. A method, comprising:

applying a cardiac rhythm management (CRM) therapy, wherein the CRM therapy is adapted to electrically capture cardiac tissue to provide a baseline response of a physiologic system to the CRM therapy;

receiving feedback for use in controlling the CRM therapy, wherein receiving feedback includes;

perturbing the physiologic system from the baseline response to cause a transient nerve traffic response in preparation to sense a nerve traffic signal to determine the transient nerve traffic response;

sensing the nerve traffic signal to determine the transient nerve traffic response to perturbing the physiologic system; and

identifying at least one feature of the nerve traffic signal indicative of the transient nerve traffic response to perturbing the physiologic system; and

using the at least one feature of the nerve traffic signal indicative of the transient nerve traffic response as feedback for the CRM therapy.

31. The method of claim 30, wherein identifying at least one feature of the nerve traffic signal includes implementing a noise reduction algorithm to identify the at least one feature of the nerve traffic signal.

32. The method of claim 31, wherein implementing a noise reduction algorithm to identify the at least one feature of the nerve traffic signal includes implementing a noise reduction algorithm to identify a nerve traffic pattern.

33. The method of claim 31, wherein implementing a noise reduction algorithm to identify the at least one feature of the nerve traffic signal includes implementing a noise reduction algorithm to identify a nerve traffic intensity.

34. The method of claim 31, wherein the noise reduction algorithm includes a wavelet transformation.

35. The method of claim 30, wherein sensing a nerve traffic signal includes sensing a nerve traffic signal using at least a first lead, and applying CRM therapy based on the at least one feature of the nerve traffic signal includes applying neural stimulation using at least the first lead.

36. The method of claim 30, wherein sensing a nerve traffic signal includes sensing a nerve traffic signal using at least a first lead, and applying neural CRM therapy based on the at least one feature of the nerve traffic signal includes applying neural stimulation using at least a second lead.

37. The method of claim 30, wherein the at least one feature includes a nerve traffic pattern.

38. The method of claim 30, wherein the at least one feature includes a nerve traffic intensity.

40. The method of claim 30, wherein sensing a nerve traffic signal includes filtering the nerve traffic signal to pass frequencies in a range from approximately 30 Hz to approximately 3,000 Hz.

41. The method of claim 30, wherein perturbing the physiologic system includes changing a parameter for a cardiac rhythm management therapy to perturb the physiologic system.

42. The method of claim 30, wherein perturbing a physiologic system includes applying a neural stimulation burst to perturb the physiologic system.

43. The method of claim 30, wherein perturbing a physiologic system includes applying a premature myocardial stimulus to perturb the physiologic system.

44. The method of claim 30, wherein the transient nerve traffic response has a duration less than 100 ms after the physiologic system is perturbed.