System and method for grading microemboli monitored by a multi-gate doppler ultrasound system

• US 7,771,358 B2
• Filed: 05/20/2005
• Issued: 08/10/2010
• Est. Priority Date: 05/20/2005
• Status: Expired due to Fees

• Current Assignee: Spentech Incorporated
• Original Assignee: Spentech Incorporated
• Inventors: Spencer, Merrill P., Dewaraja, Asanka S., Mera, Thomas O., Moehring, Mark A.
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): Fernandez; Katherine L
• Application Number:
  US11/134,862
• Publication Number:
  US 20060264759A1
• Time in Patent Office: 1,908 Days
• Field of Search: 600/454, 600/437, 600/453, 600/523, 600/438, 600/455, 600457-458, 600/469, 128/647
• US Class Current: 600/454
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain

Abstract

Systems and methods for grading signals from microemboli in blood flow monitored using a Doppler ultrasound system. Signals from microemboli in blood flow are graded by calculating a value related to a power for the signals from microemboli in blood flow and categorizing the signals into one of at least two grades based on the calculated value. Alternatively, signals can be categorized by assessing a power value for the microemboli in blood flow during a period of monitoring. In response to the power value being greater than or equal to a threshold value, the microemboli in blood flow are categorized based on the power value, and in response to the power value being less than the threshold value, a number of microemboli are counted during at least a portion of the period of monitoring and the microemboli are categorized based on the number.

Claims

1. A method for grading signals from microemboli in blood flow, the blood flow monitored using a Doppler ultrasound system, the method comprising:

for a period of monitoring and a background period, extracting Doppler shift signals from echo signals resulting from ultrasound delivered to a region in which blood flow is detected;

calculating signal-to-background data from the Doppler shift signals from the period of monitoring and the background period;

partitioning the signal-to-background data into sub-periods having corresponding portions of the signal-to-background data;

calculating correlative data from the signal-to-background data for a plurality of sub-periods; and

categorizing the signals from microemboli in blood flow into one of at least two grades based at least in part on the correlative data.

2. The method of claim 1 wherein calculating signal-to-background data from the Doppler shift signals comprises:

calculating mean background power for a depth range from the Doppler shift signals from the background period;

calculating Doppler signal power values for the depth range over the period of monitoring from the Doppler shift signals from the period of monitoring; and

dividing the Doppler signal power values by the mean background power for corresponding depths of the depth range.

3. The method of claim 2 wherein determining from the signal-to-background data the presence of microemboli in the blood flow during the period of monitoring comprises:

identifying the signal-to-background data representing a signal-to-background ratio greater than a threshold value.

4. The method of claim 1 wherein categorizing the signals from microemboli in blood flow into one of at least two grades based at least in part on the correlative data comprises:

summing the correlative data; and

categorizing the signals from microemboli in blood flow into one of at least two grades based at least in part on the sum of the correlative data.

5. The method of claim 1 wherein delivering ultrasound to a region in which blood flow is present comprises:

delivering ultrasound from first and second ultrasound probes for bilateral monitoring of the region;

wherein extracting, calculating, and determining are performed for echo signals resulting from the ultrasound delivered by the respective ultrasound probes to provide decibel values for each of the probes;

calculating beam power for the ultrasound delivered by each probe; and

the value related to the power for the microemboli is provided by weighting the decibel values for each of the probes in accordance with the beam power calculated for each probe.

6. The method of claim 1 wherein categorizing the signals from microemboli in blood flow comprises:

categorizing the signals from microemboli in blood flow into at least one high grade in response to the value being greater than or equal to a threshold value; and

in response to the value being less than the threshold value, the method further comprising;

calculating a count value corresponding to a number of signals from microemboli in the blood flow; and

categorizing the signals from microemboli in blood flow into one of a plurality of grades based on the count value.

7. The method of claim 1 wherein categorizing the signals from microemboli in blood flow into one of at least two grades comprises categorizing the signals from microemboli in blood flow into a grade of a six-level logarithmic scale.

8. The method of claim 1, further comprising:

in the event the value is greater than the threshold value, determining whether the signals from microemboli in the blood flow over a period of monitoring is graded as a first high grade or a second high grade for sub-periods of the period of monitoring.

9. The method of claim 1 wherein calculating correlative data from the signal-to-background data for a plurality of sub-periods comprises calculating correlative data from the signal-to-background data for a plurality of adjacent sub-periods.

10. The method of claim 1 further comprising storing in memory data indicative of the grade for the signals from microemboli.

11. A method for categorizing microemboli in blood flow monitored using a Doppler ultrasound system, the method comprising:

assessing a power value for the microemboli in the blood flow during a period of monitoring;

in response to the power value being greater than or equal to a threshold value, categorizing the microemboli in the blood flow based on the power value; and

in response to the power value being less than the threshold value, counting a number of microemboli during at least a portion of the period of monitoring and categorizing the microemboli based on the number.

12. The method of claim 11 wherein assessing a power value for the microemboli in the blood flow during a period of monitoring comprises assessing a power value for bubble emboli in cerebral blood flow during the period of monitoring.

13. The method of claim 12 wherein categorizing the microemboli in the blood flow based on the power value comprises categorizing the bubble emboli in a grade for a grading scale related to functional conductance of patent foramen ovale.

14. A Doppler ultrasound system, comprising:

a probe having an ultrasound transducer;

a transmitter circuit operably coupled to the ultrasound transducer and configured to generate drive signals for driving the ultrasound transducer to deliver ultrasound;

a receiver circuit operably coupled to the ultrasound transducer and configured to receive echo signals detected by the ultrasound transducer and generate in response thereto echo data representative of the echo signals; and

a processing system operably coupled to the transmitter and receiver circuits and configured to control the transmit circuit in generating drive signals for the ultrasound transducer and configured to process the echo data from the receiver circuit and extract therefrom Doppler shift signals represented by Doppler shift data for a period of monitoring and a background period, the processing system further configured to process the Doppler shift data to calculate signal-to-background data, partition the signal-to-background data into sub-periods having corresponding portions of the signal-to-background data, calculate correlative data from the signal-to-background data for a plurality of sub-periods, and categorize the signals from microemboli in blood flow into one of at least two grades based at least in part on the correlative data.

15. The system of claim 14 wherein the processing system configured to calculate signal-to-background data from the Doppler shift signals comprises a processor configured to calculate mean background power for a depth range from the Doppler shift signals from the background period, calculate Doppler signal power values for the depth range over the period of monitoring from the Doppler shift signals from the period of monitoring, and divide the Doppler signal power values by the mean background power for corresponding depths of the depth range.

16. The system of claim 14 wherein the processing system configured to process the Doppler shift data to categorize the signals from microemboli in blood flow into one of at least two grades based at least in part on the correlative values comprises a processor configured to sum the correlative data, and categorize the signals from microemboli in blood flow into one of at least two grades based at least in part on the sum of the correlative values.

17. The system of claim 14 wherein the probe comprises a first probe, the transmitter circuit comprises a first transmitter circuit, and the receiver circuit comprises a first receiver circuit, and the system further comprises a second probe having an ultrasound transducer, a second transmitter circuit operably coupled to the ultrasound transducer of the second probe, and a second receiver circuit operably coupled to the ultrasound transducer of the second probe,

the processing system comprises a processor configured to control the first and second transmit and receive circuits to deliver ultrasound from first and second probes for bilateral monitoring of a region, and the extracting, calculating, and determining are performed for echo signals resulting from the ultrasound delivered by the respective ultrasound probes to provide decibel values for each of the probes, the processor further configured to calculate beam power for the ultrasound delivered by each probe and calculate the value related to the power for the microemboli by weighting the decibel values for each of the probes in accordance with the beam power calculated for each probe.

18. The system of claim 14 wherein the processing system configured to categorize the signals from microemboli in blood flow comprises a processor configured to categorize the signals from microemboli in blood flow into at least one high grade in response to the value being greater than or equal to a threshold value and in response to the value being less than the threshold value, the processor is further configured to calculate a count value corresponding to a number of signals from microemboli in the blood flow and categorize the signals from microemboli in blood flow into one of a plurality of grades based on the count value.

19. The system of claim 14 wherein the processing system comprises a processor configured to determine whether the signals from microemboli in the blood flow over a period of monitoring is graded as a first high grade or a second high grade for sub-periods of the period of monitoring in the event the value is greater than a threshold value.

20. The system of claim 14 wherein the processing system configured to calculate correlative data from the signal-to-background data for a plurality of sub-periods comprises a processor configured to calculate correlative data from the signal-to-background data for a plurality of adjacent sub-periods.

21. A processing system for a Doppler ultrasound system having a probe having an ultrasound transducer, transmit beam forming circuits, and receive beam forming circuits, the processing system comprising:

a processor configured to extract Doppler shift signals from echo signals detected by the beam forming circuits and further configured to process the Doppler shift signals to assess a power value for microemboli in blood flow monitored by the Doppler ultrasound system during a period of monitoring and categorize microemboli in blood flow based on the power value in response to the power value being greater than or equal to a threshold value, the processor further configured to count a number of microemboli in blood flow during at least a portion of the period of monitoring and categorize the microemboli in blood flow based on the number in response to the power value being less than the threshold value.

22. The system of claim 21 wherein the processor configured to assess a power value for microemboli in the blood flow during a period of monitoring comprises a processor configured to assess a power value for bubble emboli in cerebral blood flow during the period of monitoring.

23. The system of claim 22 wherein the processor is configured to categorize the bubble emboli in a grade for a grading scale related to functional conductance of patent foramen ovale.