Resistive anti-obesity devices

• US 7,771,382 B2
• Filed: 01/11/2006
• Issued: 08/10/2010
• Est. Priority Date: 01/19/2005
• Status: Active Grant

• Current Assignee: GI Dynamics Incorporated
• Original Assignee: GI Dynamics Incorporated
• Inventors: Melanson, David A., Lamport, Ronald B., Levine, Andy H., Randle, Stuart A.
• Primary Examiner(s): Ho; (Jackie) Tan-Uyen T
• Assistant Examiner(s): Dornbusch; Dianne
• Application Number:
  US11/330,705
• Publication Number:
  US 20060161139A1
• Time in Patent Office: 1,672 Days
• Field of Search: 606/153, 606/213, 606/151, 606/191, 623/23.64, 623/23.65, 623/23.68, 623/23.7, 600/32, 600/37, 128/830, 128/831, 128/898, 604/8, 604/9
• US Class Current: 604/9
• CPC Class Codes: A61F 2002/044 Oesophagi or esophagi or gullets
• CPC Class Codes: A61F 5/0079 Pyloric or esophageal obstructions

Abstract

A patient is provided with an increased sense of satiety by increasing resistance to the outflow of food from the stomach and through the intestines. Stomach emptying may be slowed with devices implantable within the gastrointestinal tract below the stomach. Implants are preferably removable and can include artificial strictures that may be adjustable to vary the rate of stomach emptying. Slowing gastric emptying may induce satiety for a longer period and may therefore reduce food consumption. Many of the embodiments include intestinal liners or sleeves, but they need not. The resistor concept may be applied to a simple anchor and resistor without a long liner.

Claims

1. A method for treating obesity comprising:

implanting a device within a gastrointestinal tract of an animal, the implanted device having an orifice retained at less than 10 millimeters in diameter, the device implanted entirely in the intestine of the animal; and

with the orifice of the implanted device retained at less than 10 millimeters in diameter, resisting the outflow of chyme from the stomach into the intestines while allowing flow of chyme.

2. The method of claim 1, wherein the step of implanting comprises a non-surgical procedure.

3. The method of claim 2, wherein the non-surgical procedure comprises an endoscopic procedure.

4. The method of claim 1, further comprising adjusting the orifice to vary the resistance provided to the outflow of chyme from the stomach, the adjusted orifice retained at a new diameter.

5. The method of claim 4, wherein adjusting the orifice includes expanding the orifice.

6. The method of claim 5, wherein the orifice is expanded by inflating a balloon.

7. The method of claim 1, wherein the implantable device has a textured surface exposed to resist the natural flow of chyme.

8. The method of claim 1, wherein the implanting step comprises removably anchoring the device within the gastrointestinal tract.

9. The method of claim 1, further comprising removing the device from the gastrointestinal tract.

10. The method of claim 1, wherein the orifice is an aperture in a membrane.

11. The method of claim 10 wherein the membrane is elastomeric.

12. The method of claim 1, wherein the implant further comprises an elongated liner defining a lumen through which chyme passes.

13. The method of claim 1, wherein the orifice is between about 3 mm and about 5 mm in diameter.

14. The method of claim 13, further comprising expanding the orifice, the expanded orifice retained at a new diameter.

15. The method of claim 14, wherein the orifice is expanded by inflating a balloon.

16. The method of claim 1, wherein the device further includes an anchor, wherein the anchor has a relaxed diameter of at least 40 mm.

17. The method of claim 16, wherein the anchor has a relaxed diameter of at least 45 mm.

18. The method of claim 16, wherein the anchor is a wave anchor.

19. The device of claim 1, wherein the orifice is at least 2 millimeters in diameter.

20. A method for treating obesity comprising:

implanting a device within a gastrointestinal tract of an animal, the device having a diaphragm, the diaphragm having a hole in a membrane, the hole having an area and being less than 10 millimeters in diameter, there being an open volume before and after the diaphragm, each open volume having a cross-sectional area substantially greater than the hole area; and

with the diaphragm, resisting the outflow of chyme from the stomach into the intestines through the hole.

21. The method of claim 20, wherein the device is anchored distal to the pylorus.

22. The method of claim 21, wherein the device is anchored with a wave anchor.

23. The method of claim 20, wherein the device further comprises an elongated liner defining a lumen through which chyme passes.

24. The method of claim 23, wherein the diaphragm is within the elongated liner.

25. The method of claim 20, wherein the hole is between about 3 mm and about 5 mm in diameter.

26. The method of claim 25, further comprising expanding the hole to reduce the resistance provided to the outflow of chyme from the stomach.

27. The method of claim 26, wherein the hole is expanded by inflating a balloon.

28. The method of claim 20 wherein the membrane is elastomeric.

29. The method of claim 20, wherein the hole is at least 2 millimeters in diameter.

30. The method of claim 20, further comprising expanding the hole to reduce the resistance provided to the outflow of chyme from the stomach.

31. The method of claim 30, wherein the hole is expanded by inflating a balloon.