Pen shaped medication injection devices

• US 7,771,398 B2
• Filed: 12/30/2005
• Issued: 08/10/2010
• Est. Priority Date: 01/18/2005
• Status: Active Grant

• Current Assignee: Wockhardt USA LLC (Wockhardt Limited)
• Original Assignee: Wockhardt Limited
• Inventors: Sesha, Ramesh, Srinivas, Venkitraman R, Knowles, Stephen, Knight, Barry
• Primary Examiner(s): Sirmons; Kevin C
• Assistant Examiner(s): Gilbert; Andrew M
• Application Number:
  US11/320,809
• Publication Number:
  US 20060184117A1
• Time in Patent Office: 1,684 Days
• Field of Search: 604/135, 604207-211
• US Class Current: 604/208
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/585 having magnification means, e.g. magnifying glasses
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/3155 by rotational movement of dose setting member, e.g. during setting or filling of a syringe
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31561 using freely adjustable volume steps
• CPC Class Codes: A61M 5/31578 based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/31585 performed by axially moving actuator, e.g. an injection button

Abstract

The present invention provides a delivery device comprising a fluid cartridge holder, housing and a piston drive mechanism that comprises a hollow piston rod and a drive-shaft. The hollow piston rod has an internal thread that mates with the external thread of the drive-shaft, forming a thread connection and being axially restrained in the proximal direction relative to the housing. The drive mechanism is in turn connected to the housing via a one way ratchet such that the piston rod is prevented from moving in the proximal direction.

Claims

1. A delivery device that comprises:

a fluid cartridge holder comprising a cartridge containing fluid,

a housing,

a piston drive mechanism situated within the housing and comprising a hollow piston rod and a drive-shaft,

which hollow piston rod has an internal thread on at least a portion of its inner surface and a non-circular outer section,

and which drive-shaft has an external thread which mates with the internal thread of the hollow piston rod forming a thread connection and being axially restrained in the proximal direction relative to the housing,

a piston drive mechanism for rotating the drive-shaft such that upon activation of the driving mechanism the piston rod is forced to move axially in the distal direction causing ejection of the fluid from the cartridge, the delivery device further characterized in that the internal threads on the hollow piston rod and the external threads on the drive shaft are not exposed when the cartridge holder is removed.

2. A delivery device according to claim 1 wherein the piston rod is prevented from rotating by a locking bush with an inner profile which mates with the non-circular outer section of the piston rod, and wherein the housing comprises a concentrically arranged outer housing-tube and an inner housing-tube.

3. A delivery device according to claim 2 wherein the piston drive mechanism is connected to the housing via a one way ratchet such that the piston rod is prevented from moving axially.

4. A delivery device according to claim 3 wherein the piston drive mechanism is connected to the housing via a one way ratchet such that the piston rod is prevented from moving axially in the proximal direction.

5. A delivery device according to claim 4 wherein the drive-shaft is connected to the housing via a one way ratchet such that the drive shaft is prevented from rotating in the direction which would result in movement of the piston rod axially in the proximal direction.

6. A delivery device according to claim 1 wherein the housing comprises a concentrically arranged outer housing-tube and an inner housing-tube.

7. A delivery device according to claim 6 wherein the piston drive mechanism is located within the inner housing-tube.

8. A delivery device according to claim 7 wherein the piston drive mechanism is connected to the inner housing-tube via a one way ratchet such that the piston rod is prevented from moving axially.

9. A delivery device according to claim 8 wherein the piston drive mechanism is connected to the inner housing-tube via a one way ratchet such that the piston rod is prevented from moving axially in the proximal direction.

10. A delivery device according to claim 9 wherein the drive-shaft is connected to the inner housing-tube via a one way ratchet such that the drive-shaft is prevented from rotating in the direction which would result in movement of the piston axially.

11. A delivery device according to claim 10 wherein the drive-shaft is connected to the inner housing-tube via a one way ratchet such that the drive-shaft is prevented from rotating in the direction which would result in movement of the piston axially in the proximal direction.

12. A delivery device according to claim 11 wherein the drive-shaft comprises ratchet teeth that inter digit correspondingly located teeth on the inner housing-tube to form the one-way ratchet.

13. A delivery device according to claim 12 wherein the ratchet teeth are present on the drive-shaft.

14. A delivery device according to claim 13 wherein the ratchet teeth are present on the proximal region of the drive-shaft.

15. A delivery device according to claim 2 wherein the locking bush is located between the piston rod and the inner housing-tube.

16. A delivery device according to claim 15 wherein the locking bush is located between the distal end of the piston rod and the inner housing-tube.

17. A delivery device according to claim 16 in which the inner profile of the locking bush are protrusions that mate with longitudinal channels that traverse the length of the non-circular outer portion of the piston rod, thereby preventing the piston rod from rotating.

18. A delivery device according to claim 17 in which the locking bush further comprises an outer toothed surface.

19. A delivery device according to claim 18 wherein the portions of the inner housing-tube are further molded as two sprung clips.

20. A delivery device according to claim 19 wherein the portions of the distal portion of the inner housing-tube are further molded as two sprung clips.

21. A delivery device according to claim 20 wherein the sprung clips further comprise an inner toothed surface that engage with the outer toothed surface of the locking bush.

22. A delivery device according to claim 1 further comprising:

a dose setting means comprising,

an outer dose-drum located within the housing, wherein the outer dose-drum and the housing are mated by a non locking helical thread-rib arrangement,

an inner dose-drum rotationally connected to the drive-shaft and located within the outer dose-drum and capable of being rotationally connected or disconnected from the outer dose-drum, so that when rotationally disconnected, the outer dose-drum can be rotated spirally outwards in the proximal direction to set a dose, or spirally inwards to set a lower dose; and

when rotationally connected to the outer dose-drum will transmit the rotation of the outer dose-drum to the drive-shaft forcing the piston rod out.

23. A delivery device according to claim 22 further comprising:

a dose setting means comprising,

an outer dose-drum located within the housing, wherein the outer dose-drum and the housing are mated by a non locking helical thread-rib arrangement,

an inner dose-drum rotationally connected to the drive-shaft and located within the outer dose-drum and capable of being rotationally connected or disconnected from the outer dose-drum, so that when rotationally disconnected, the outer dose-drum can be rotated spirally outwards in the proximal direction to set a dose, or spirally inwards to set a lower dose; and

when rotationally connected to the outer dose-drum will transmit the rotation of the outer dose-drum to the drive-shaft forcing the piston rod out in the distal direction.

24. A delivery device according to claim 23 wherein the outer dose-drum and the inner dose-drum are located between the outer housing-tube and inner housing-tube.

25. A delivery device according to claim 24 in which the outer dose-drum and the outer housing-tube are mated by a helical thread-rib arrangement.

26. A delivery device according to claim 25 wherein,

when the piston drive mechanism is activated, the inner dose-drum, that is rotationally connected to the drive-shaft, gets rotationally connected with the outer dose-drum, and will transmit the rotation of the outer dose-drum to the drive-shaft which in turn forces the piston rod to move axially;

and when the driving mechanism is not activated, the inner dose-drum, that is rotationally connected to the drive-shaft, gets rotationally disconnected from the outer dose-drum, so that the outer dose-drum can be rotated spirally outwards to set a dose, and spirally inwards to set a lower dose.

27. A delivery device according to claim 26 wherein,

when the piston drive mechanism is activated, the inner dose-drum, that is rotationally connected to the drive shaft, gets rotationally connected with the outer dose-drum, and will transmit the rotation of the outer dose-drum to the drive-shaft which in turn forces the piston rod to move axially in the distal direction;

and when the driving mechanism is not activated, the inner dose-drum, that is rotationally connected to the drive-shaft, gets rotationally disconnected from the outer dose-drum, so that the outer dose-drum can be rotated spirally outwards in the proximal direction to set a dose, and spirally inwards to set a lower dose.

28. A delivery device according to claim 27 wherein the inner surface of the inner dose-drum is rotationally connected to the drive-shaft.

29. A delivery device according to claim 28 wherein the inner surface of the inner dose-drum is rotationally connected to legs present on the drive-shaft.

30. A delivery device according to claim 29 wherein the inner surface of the inner dose-drum is rotationally connected to legs present on the proximal portion of the drive-shaft.

31. A delivery device according to claim 30 wherein the said legs are connected to channels that traverse the inner surface of the inner dose-drum.

32. A delivery device according to claim 22 wherein the piston drive mechanism is activated by depressing a thumb pad.

33. A delivery device according to claim 32 wherein,

when the piston drive mechanism is activated, the inner dose-drum, that is rotationally connected to the drive-shaft by legs, gets rotationally connected with the outer dose-drum, and will transmit the rotation of the outer dose-drum to the drive-shaft which in turn forces the piston rod to move axially,

and when the driving mechanism is inactivated, the inner dose-drum, that is rotationally connected to the drive-shaft, gets rotationally disconnected from the outer dose-drum, so that the outer dose-drum can be rotated spirally outwards to set a dose, and spirally inwards to set a lower dose.

34. A delivery device according to claim 33 wherein,

when the piston drive mechanism is activated, the inner dose-drum, that is rotationally connected to the drive-shaft by legs, gets rotationally connected with the outer dose-drum, and will transmit the rotation of the outer dose-drum to the drive-shaft which in turn forces the piston rod to move axially in the distal direction;

and when the driving mechanism is inactivated, the inner dose-drum, that is rotationally connected to the drive-shaft, gets rotationally disconnected from the outer dose-drum, so that the outer dose-drum can be rotated spirally outwards in the proximal direction to set a dose, and spirally inwards to set a lower dose.

35. A delivery device according to claim 34 that further comprises, on the outer surface of the inner dose-drum, sprung ridge teeth that contact with inner mating teeth that are arrayed along the inner circumference of the outer dose-drum such that the said sprung ridge teeth and inner mating teeth mate with each other at an angle to the axis of rotation.

36. A delivery device according to claim 35 that further comprises, on the outer surface of the inner dose-drum, close to its proximal end, sprung ridge teeth that contact with inner mating teeth that are arrayed along the inner circumference of the outer dose-drum on the proximal end, such that the said sprung ridge teeth and inner mating teeth mate with each other at an angle to the axis of rotation.

37. A delivery device according to claim 36 that further comprises,

on the outer surface of the inner dose-drum but located distal to the sprung ridge teeth, engagement teeth,

on the outer dose-drum, circularly arrayed teeth, the location being distal with respect to that of the engagement teeth,

the relative location of the engagement teeth and the circularly arrayed teeth with respect to each other being such that, when the thumb pad is depressed, the said engagement teeth and circularly arrayed teeth get interlocked, and when the thumb pad is released, the axial spring force between the sprung ridge teeth and the mating teeth force the interlock between the engagement teeth and the circularly arrayed teeth apart.

38. A delivery device according to claim 37 that further comprises,

on the outer surface of the inner dose-drum on its proximal region, but located distal to the sprung ridge teeth, engagement teeth,

on the proximal region of the outer dose-drum, circularly arrayed teeth, the location being distal with respect to that of the engagement teeth,

the relative location of the engagement teeth and the circularly arrayed teeth with respect to each other being such that, when the thumb pad is depressed, the said engagement teeth and circularly arrayed teeth get interlocked, and when the thumb pad is released, the axial spring force between the sprung ridge teeth and the mating teeth force the interlock between the engagement teeth and the circularly arrayed teeth apart.

39. A deliver device according to claim 38 wherein when the piston drive mechanism is activated, the engagement teeth and the circularly arrayed teeth are interlocked, and the inner dose-drum is rotationally connected with the outer dose-drum, and transmits the rotation of the outer dose-drum to the drive-shaft which in turn forces the piston rod to move axially, and

when the drive mechanism is inactivated, the interlock between the engagement teeth and the circularly arrayed teeth are parted, and inner dose-drum is rotationally disconnected with the outer dose-drum, so that the outer dose-drum can be rotated spirally outwards to set a dose, and spirally inwards to set a lower dose.

40. A deliver device according to claim 39 wherein when the piston drive mechanism is activated, the engagement teeth and the circularly arrayed teeth are interlocked, and the inner dose-drum is rotationally connected with the outer dose-drum, and will transmit the rotation of the outer dose-drum to the drive-shaft which in turn forces the piston rod to move axially in the distal direction, and

when the drive mechanism is inactivated, the interlock between the engagement teeth and the circularly arrayed teeth are parted, and inner dose-drum is rotationally disconnected with the outer dose-drum, so that the outer dose-drum can be rotated spirally outwards in the proximal direction to set a dose, and spirally inwards to set a lower dose.

41. A delivery device according to claim 40 wherein the drive mechanism comprises a thumb pad.

42. A delivery device according to claim 41 wherein the thumb pad is present at the inner dose-drum.

43. A delivery device according to claim 42 wherein the thumb pad is present at the proximal end of the inner dose-drum.

44. A delivery device according to claim 43 wherein the thumb pad is free to rotate on a bearing surface at the proximal end of the inner dose-drum.

45. A delivery device according to claim 44 wherein the drive mechanism is activated by depressing the thumb pad.