Selective renal cannulation and infusion systems and methods

• US 7,771,401 B2
• Filed: 06/05/2007
• Issued: 08/10/2010
• Est. Priority Date: 06/08/2006
• Status: Expired due to Fees

• Current Assignee: AngioDynamics, Inc.
• Original Assignee: AngioDynamics, Inc.
• Inventors: Goodson, Harry B., Valencia, Aurelio, Elkins, Jeffrey M., Hekmat, Neema
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): Stigell; Theodore J
• Application Number:
  US11/758,417
• Publication Number:
  US 20070287967A1
• Time in Patent Office: 1,162 Days
• Field of Search: 604/43, 604/95.04, 604/158, 604246-247, 604530-532, 604/537, 604104-107, 604/284
• US Class Current: 604/246
• CPC Class Codes: A61M 2025/0034 characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores
• CPC Class Codes: A61M 2025/0037 characterized by lumina being arranged side-by-side
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
• CPC Class Codes: A61M 2025/024 having a clip or clamp system
• CPC Class Codes: A61M 2025/1045 for treating bifurcations, e.g. balloons in y-configuration, separate balloons or special features of the catheter for treating bifurcations
• CPC Class Codes: A61M 25/0028 characterized by features relating to at least one lumen located at the proximal part of the catheter, e.g. alterations in lumen shape or valves catheter hubs A61M25/0097
• CPC Class Codes: A61M 25/0029 characterized by features relating to least one lumen located at the middle part of the catheter, e.g. slots, flaps, valves, cuffs, apertures, notches, grooves or rapid exchange ports catheter shaft surface irregularities A61M2025/006
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0071 Multiple separate lumens multiple separate lumens throughout the catheter A61M25/0026
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/0075 Valve means
• CPC Class Codes: A61M 25/008 Strength or flexibility characteristics of the catheter tip
• CPC Class Codes: A61M 25/02 Holding devices, e.g. on the body

Abstract

Renal infusion systems include an infusion catheter having a bifurcated distal end with a first branch and second branch, the branches being biased to deploy laterally when unconstrained. Systems also include a delivery sheath having a lumen which receives the infusion catheter and constrains the first branch and second branch. A distal opening of the delivery sheath is formed asymmetrically to allow one of the first and second branches to open laterally while the other of the branches remains constrained. Methods of using renal infusion systems are also provided.

Claims

1. A renal infusion system, comprising:

an infusion catheter having a bifurcated distal end with a first branch and second branch, said branches being biased to deploy laterally when unconstrained; and

a delivery sheath having a lumen which receives the infusion catheter and constrains the first branch and second branch;

wherein one of the first and second branches opens laterally through a distal opening of the delivery sheath while the other of the first and second branches remains fully constrained within the delivery sheath, and

wherein the first branch comprises a first branch lumen and a first branch infusion port, and the second branch comprises a second branch lumen and a second branch infusion port.

2. A renal infusion system as in claim 1, wherein the distal opening comprises an elongate structure on one side of the sheath and is free from a constraining structure on the other side of the sheath.

3. A renal infusion system as in claim 1, wherein the distal opening is chamfered.

4. A renal infusion system as in claim 1, wherein the distal opening has an axial deployment window opposite to a solid wall.

5. A renal infusion system as in claim 4, wherein the delivery sheath has a lateral protrusion proximal and diametrically opposite to the axial deployment window, wherein the protrusion can balance a force caused by deployment of a single branch of the infusion catheter.

6. A renal infusion system as in claim 1, wherein the delivery sheath comprises a detectable marker disposed adjacent the distal opening.

7. A renal infusion system as in claim 1, wherein the delivery sheath comprises a first detectable marker disposed proximally adjacent to the distal opening and a second detectable marker disposed laterally adjacent to the distal opening.

8. A renal infusion system as in claim 7, wherein the first detectable marker is disposed on a first side of the sheath and the second detectable marker is disposed on a second side of the sheath that is opposite to the first side.

9. A renal infusion system as in claim 1, wherein the delivery sheath comprises a semi circular curve disposed proximal to the distal opening, such that an arc of the semi circular curve projects in a first direction, and the distal opening faces a second direction opposite to the first direction.

10. A renal infusion system as in claim 1, further comprising an attachment means configured to secure the delivery sheath with a vessel access site of a patient.

11. An infusion catheter, comprising:

a catheter body having a distal end with a first branch, said branch being biased to deploy laterally when unconstrained; and

a first valve structure disposed between a main lumen in the catheter body and a branch lumen in the first branch, wherein said first valve structure is closed when the first branch is undeployed and opens in response to lateral deployment of the first branch.

12. An infusion catheter as in claim 11, wherein the distal end is bifurcated and further comprises a second branch that is biased to deploy laterally when unconstrained, the infusion catheter further comprising a second valve structure disposed between the main lumen and a branch lumen in the second branch, wherein said second valve structure is closed when the second branch is undeployed and opens in response to lateral deployment of the second branch.

13. An infusion catheter as in claim 12, wherein the first branch is longer than the second branch.

14. An infusion catheter as in claim 11, wherein the first valve comprises a two-way valve.

15. An infusion catheter as in claim 11, wherein the first valve comprises a pressure regulated valve that remains closed when a distal side fluid pressure is greater than an aortic blood pressure of the patient.

16. A renal infusion system, comprising:

a delivery sheath configured for placement within an aorta of a patient;

a first catheter branch configured for advancement through the delivery sheath toward a first renal artery of the patient;

a first flow path that passes through the first catheter branch to provide a first fluid flow toward the first renal artery;

a first valve that regulates the first flow path when the first branch is in a constrained and released configuration;

a second catheter branch configured for advancement through the delivery sheath toward a second renal artery of the patient;

a second flow path that passes through the second catheter branch to provide a second fluid flow toward the second renal artery; and

a second valve that regulates the second flow path when the second branch is in a constrained and released configuration; and

wherein the first fluid flow through the first flow path is greater when the first branch is in the released configuration than when it is in the constrained configuration.

17. The system of claim 16, wherein the delivery sheath comprises a marker.

18. The system of claim 16, wherein the first branch is in the constrained configuration when disposed within the delivery sheath, and is in the released configuration when advanced through a deployment window of the delivery sheath.

19. The system of claim 16, wherein the first valve comprises a first notch valve that constricts the first flow path when the first branch is in the constrained configuration, and that dilates the first flow path when the first branch is in the released configuration.

20. The system of claim 16, wherein the delivery sheath comprises a semi circular curve disposed proximal to the deployment window, such that an arc of the semi circular curve projects in a first direction, and the deployment window faces a second direction opposite to the first direction.

21. The system of claim 16, wherein the first branch comprises a marker.

22. The system of claim 16, wherein the first valve comprises a two-way valve.

23. The system of claim 16, wherein the first valve comprises a pressure regulated valve that remains closed when a distal side fluid pressure is greater than an aortic blood pressure of the patient.

24. The system of claim 16, further comprising an attachment means configured to secure the delivery sheath with a vessel access site of the patient.

25. The system of claim 16, wherein the first catheter branch is longer than the second catheter branch.