Electrochemical determination of analytes
First Claim
1. A method for determination of an analyte with increased accuracy comprising the steps of:
- (a) electrochemically determining an initial measurement value of analyte concentration in a liquid sample disposed between a working and a counter electrode,(b) performing a plurality of amperometric/potentiometric switching cycles between the working and counter electrodes,(c) observing a characteristic of the signal during each of the plurality of switching cycles,(d) determining an averaged value for the characteristic of the signal, and(e) correcting the initial measurement value to arrive at a final measurement value of analyte concentration or rejecting the initial measurement value depending on the averaged value of the characteristic of the signal.
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Accused Products
Abstract
Determination of an analyte with increased accuracy is achieved by electrochemically determining an initial analyte concentration, performing a plurality of amperometric/potentiometric switching cycles, observing a characteristic of the signal during each of the plurality of switching cycles, determining an averaged value for the characteristic of the signal, and correcting the initial measurement value to arrive at a final measurement value of analyte concentration or rejecting the initial measurement value depending on the averaged value of the characteristic of the signal. The characteristic of the signal that is observed is not per se indicative of the amount of analyte present in a sample. Rather, it is a characteristic of the signal that reflects the quality of the electrodes, the extent of fill of the electrochemical cell or characteristics of the sample other than analyte concentration such as oxygen levels or hematocrit.
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Citations
21 Claims
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1. A method for determination of an analyte with increased accuracy comprising the steps of:
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(a) electrochemically determining an initial measurement value of analyte concentration in a liquid sample disposed between a working and a counter electrode, (b) performing a plurality of amperometric/potentiometric switching cycles between the working and counter electrodes, (c) observing a characteristic of the signal during each of the plurality of switching cycles, (d) determining an averaged value for the characteristic of the signal, and (e) correcting the initial measurement value to arrive at a final measurement value of analyte concentration or rejecting the initial measurement value depending on the averaged value of the characteristic of the signal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification