Gene upregulated in cancers of the prostate

• US 7,771,968 B2
• Filed: 07/09/2008
• Issued: 08/10/2010
• Est. Priority Date: 10/28/1999
• Status: Expired due to Term

• Current Assignee: Agensys, Inc. (Astellas Pharma Incorporated)
• Original Assignee: Agensys, Inc. (Astellas Pharma Incorporated)
• Inventors: Raitano, Arthur B., Afar, Daniel E. H., Jakobovits, Aya, Hubert, Rene S., Mitchell, Steve Chappell
• Primary Examiner(s): Helms; Larry R.
• Assistant Examiner(s): DAVIS, MINH TAM B
• Application Number:
  US12/170,208
• Publication Number:
  US 20090074797A1
• Time in Patent Office: 762 Days
• Field of Search: 435/69.1, 435/240.2, 435/252.3, 435/254.2, 536/23.1
• US Class Current: 435/69.1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C12N 2799/026 where the vector is derived from a baculovirus
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ID NO: 2), is provided herein.

Claims

1. A method of expressing a polypeptide, comprising:

providing a host cell which comprises an expression vector comprising a polynucleotide sequence of SEQ ID NO;

1, which encodes the polypeptide of SEQ ID NO;

2; and

culturing the host cell under conditions wherein the polypeptide is expressed.

2. The method of claim 1, further comprising recovering the polypeptide.

3. The method of claim 1, wherein the host cell is a eucaryotic cell.

4. The method of claim 3, wherein the eucaryotic cell is a Chinese Hamster Ovary cell.

5. The method of claim 3, wherein the eucaryotic cell is a yeast cell.

6. The method of claim 3, wherein the eucaryotic cell is a plant cell.

7. The method of claim 1, wherein the host cell is a prokaryotic cell.

8. The method of claim 7, wherein the prokaryotic cell is a bacterial cell.

9. The method of claim 8, wherein the bacterial cell is an E. coli cell.