Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents

• US 7,772,359 B2
• Filed: 09/09/2008
• Issued: 08/10/2010
• Est. Priority Date: 12/19/2003
• Status: Active Grant

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Pacetti, Stephen D.
• Primary Examiner(s): WOODWARD, ANA LUCRECIA
• Application Number:
  US12/207,419
• Publication Number:
  US 20090012606A1
• Time in Patent Office: 700 Days
• Field of Search: 424/423, 424/426, 427/2.1, 427/2.14, 427/2.24, 427/340, 427/371, 427/384, 525/291, 525/292, 525/300, 525/308, 525/308.6, 525/335, 525/340, 623/1.1, 623/1.15
• US Class Current: 528/288
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: C08G 69/44 Polyester-amides
• CPC Class Codes: Y10T 428/31551 Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
• CPC Class Codes: Y10T 428/31725 Of polyamide

Abstract

This disclosure provides a method device and a method of forming the medical device. The medical device comprises a coating comprising a polymer. The polymer comprises at least two different blocks, at least one L1 block with the formula

and at least one L2 block with the formula

Medical devices comprising these polymers, mixtures of these polymers with therapeutic agents, and methods of making these polymers and mixtures are within the scope of this disclosure.

Claims

1. A medical device comprising a type-one polymer, the type-one polymer comprising at least two different blocks,

wherein the blocks-comprise at least one L1 block and at least one L2 block and are selected from

a) at least one L1 block with the formula

2. The medical device of claim 1, wherein R includes oligomers of ethylene glycol, propylene glycol (1,2- and 1,3-substituted isomers), tetramethylene glycol (1,2-, 1,3-, 1,4-, and 2,3-substituted isomers), hexamethylene glycol (1,2-, 1,3-, 1,4-1,5-, 1,6-, 2,3-, 2,4-, 2,5-, 3,4-substituted isomers);

or their mixtures.

3. The medical device of claim 1, wherein Y and Z of L1 are independently selected from

4. The medical device of claim 1, wherein Y and Z of L1 are independently selected from

5. The medical device of claim 1, wherein the type-one polymer is coated onto the surface of the device to form a layer of polymer.

6. A method for coating a medical device, comprising depositing on to the surface of the medical device a coating comprising a type-one polymer, the type-one polymer comprising at least two different blocks,

wherein the blocks-comprise at least one L1 block and at least one L2 block and are selected from

g) at least one L1 block with the formula

7. The method of claim 6, wherein R includes oligomers of ethylene glycol, propylene glycol (1,2- and 1,3-substituted isomers), tetramethylene glycol (1,2-, 1,3-, 1,4-, and 2,3-substituted isomers), hexamethylene glycol (1,2-, 1,3-, 1,4-1,5-, 1,6-, 2,3-, 2,4-, 2,5-, 3,4-substituted isomers);

or their mixtures.

8. The method of claim 6, wherein Y and Z of L1 are independently selected from

9. The method of claim 6, wherein Y and Z of L1 are independently selected from

10. The method of claim 6, wherein the type-one polymer is deposited in a layer of 0.5-500 microns thick onto the surface of the medical device.