Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness
First Claim
1. A method for early detection of subacute, potentially catastrophic illness in an infant comprising:
- (a) monitoring the infant'"'"'s RR intervals;
(b) generating a normalized data set of the RR intervals;
(c) calculating at least one of (i) moments of the data set selected from the third and higher moments, and (ii) percentile values of the data set; and
(d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and percentile values.
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Abstract
In one aspect of the invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature newborn infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect of the present invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient. The method comprises: (a) continuously monitoring the patient'"'"'s RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and the percentile values.
10 Citations
9 Claims
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1. A method for early detection of subacute, potentially catastrophic illness in an infant comprising:
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(a) monitoring the infant'"'"'s RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating at least one of (i) moments of the data set selected from the third and higher moments, and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and percentile values. - View Dependent Claims (2, 3, 4, 5)
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6. An apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient, wherein the patient is selected from the group consisting of a premature newborn infant, infant, newborn infant, toddler and child, comprising (1) a monitoring device, continuously monitoring the patient'"'"'s RR intervals, and (2) a microprocessor, said microprocessor performing steps comprising:
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(a) generating a normalized data set of the RR intervals; (b) calculating at least one of (i) moments of the data set selected from the third and higher moments, and (ii) percentile values of the data set; and (c) identifying an abnormal heart rate variability based on one or more of the moments and the percentile values. - View Dependent Claims (7, 8, 9)
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Specification