Medical fluid pumping system having real time volume determination

• US 7,776,006 B2
• Filed: 07/05/2007
• Issued: 08/17/2010
• Est. Priority Date: 11/05/2003
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Childers, Robert W., Hopping, Peter A.
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): HOLLOWAY, IAN KNOBEL
• Application Number:
  US11/773,773
• Publication Number:
  US 20080015493A1
• Time in Patent Office: 1,139 Days
• Field of Search: 604/131, 604/29, 604/6.11, 604/401, 604/67, 210/258, 417/395
• US Class Current: 604/67
• CPC Class Codes: A61M 1/1522 the interface being evacuated interfaces to enhance contact
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/159 specially adapted for peritoneal dialysis
• CPC Class Codes: A61M 1/1635 with volume chamber balancing devices between used and fresh dialysis fluid
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1664 with temperature control
• CPC Class Codes: A61M 1/167 Flexible packaging for solid concentrates
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/281 Instillation other than by gravity
• CPC Class Codes: A61M 1/282 Operational modes
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 1/288 Priming priming in extracorporeal blood circuits A61M1/3643
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3434 with pre-dilution and post-dilution
• CPC Class Codes: A61M 1/3458 having electrolytes not present in the dialysate
• CPC Class Codes: A61M 1/3643 Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 Mode of operation
• CPC Class Codes: A61M 1/3647 : with recirculation of the priming solution
• CPC Class Codes: A61M 1/3652 : using gas, e.g. air
• CPC Class Codes: A61M 2205/12 : with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/3368 : Temperature
• CPC Class Codes: A61M 2205/3372 : Temperature compensation

Abstract

A medical fluid pumping system includes a medical fluid pump; a first pressure chamber connected fluidly to the medical fluid pump; a second pressure chamber connected fluidly to the medical fluid pump; first and second pressure sensors connected operably to the first and second pressure chambers, respectively; and at least one processor operable with the pressure sensors to calculate a volume of gas in the medical fluid pump prior to a pump-out stroke using a reading from the first pressure sensor after exposing the pump to gas pressure from the first pressure chamber and to use the calculated volume of gas in combination with a known volume of the second pressure chamber and a pressure decay reading taken via the second pressure sensor during the pump-out stroke to calculate at least one volume of fluid pumped during the pump-out stroke.

Claims

1. A medical fluid pumping system comprising:

a medical fluid pump;

a first pressure chamber separate from and connected fluidly to the medical fluid pump;

a second pressure chamber separate from and connected fluidly to the medical fluid pump;

first and second pressure sensors connected operably to the first and second pressure chambers, respectively;

at least one processor operable with the pressure sensors to calculate a volume of gas in the medical fluid pump prior to a pump-out stroke using a reading from the first pressure sensor after exposing the pump to gas pressure from the first pressure chamber and to use the calculated volume of gas in combination with a known volume of the second pressure chamber and a pressure decay reading taken via the second pressure sensor during the pump-out stroke to calculate at least one volume of fluid pumped during the pump-out stroke; and

wherein the medical fluid pump is exposed to gas pressure from the second pressure chamber to perform the pump-out stroke.

2. The medical fluid pumping system of claim 1, wherein the gas is air.

3. The medical fluid pumping system of claim 1, which includes a reference chamber connected fluidly to the medical fluid pump, the reference chamber used to calculate the volume of gas in the medical fluid pump.

4. The medical fluid pumping system of claim 3, which includes a thermal coupling of the medical fluid pump to the reference chamber, tending to make a temperature of gas in the pump at least substantially equal to a temperature of gas in the reference chamber.

5. The medical fluid pumping system of claim 3, which includes at least one valve selected from the group consisting of:

(i) a vent valve between the reference chamber and atmosphere;

(ii) a valve between the medical fluid pump and the reference chamber;

(iii) a valve between the medical fluid pump and the first pressure chamber; and

(iv) a valve between the medical fluid pump and the second pressure chamber.

6. The medical fluid pumping system of claim 3, wherein the volume of gas in the medical fluid pump V_gas is calculated according to an equation

V_gas=(P_{ref, final}−

P_{ref, initial})/(P_{press1, initial}−

P_{press1, final})*V_ref, wherein

(i) P_ref,final is a final pressure in the reference chamber after the medical fluid pump is exposed to gas pressure from the first pressure chamber;

(ii) P_ref,initial is an initial pressure in the reference chamber before the medical fluid pump is exposed to gas pressure from the first pressure chamber;

(iii) P_{press1, initial} is an initial pressure in the first pressure chamber before the medical fluid pump is exposed to gas pressure from the first pressure chamber;

(iv) P_{press1, final} is a final pressure in the first pressure chamber after the medical fluid pump is exposed to gas pressure from the first pressure chamber; and

(V) V_ref is the volume of the reference chamber.

7. The medical fluid pumping system of claim 1, wherein the at least one volume of fluid pumped during the pump-out stroke V_fluid,t is calculated according to an equation

V_fluid,t=(P_{press2, initial}/P_press2,t−

1)(V_press2+V_gas), wherein

(i) wherein P_{press2,initial} is an initial pressure of the second pressure chamber prior to the pump-out stroke;

(ii) P_press2,t is a pressure of the second pressure chamber at a time t during the pump-out stroke;

(iii) V_press2 is a known volume of the second pressure chamber; and

(iv) V_gas is the calculated volume of gas in the medical fluid pump.

8. The medical fluid pumping system of claim 1, wherein the medical fluid pump has at least one characteristic selected from the group consisting of:

(i) being operated via positive and negative pressures; and

(ii) being part of a medical fluid cassette.

9. The medical fluid pumping system of claim 1, wherein the medical fluid pump is a first medical fluid pump, and which includes a second medical fluid pump.

10. The medical fluid pumping system of claim 9, wherein the second medical fluid pump has at least one characteristic selected from the group consisting of:

(i) being configured to perform a pump-in stroke when the first medical fluid pump is performing the pump-out stroke;

(ii) being operated via positive and negative pressure;

(iii) being a membrane pump;

(iv) being part of a medical fluid cassette;

(v) being connected fluidly to the same first pressure chamber as the first medical fluid pump;

(vi) being connected fluidly to a different second pressure chamber as the first medical fluid pump; and

(vii) being connected fluidly to a separate reference chamber from a reference chamber connected fluidly to the first fluid pump.

11. The medical fluid pumping system of claim 9, wherein the at least one processor is further configured to calculate a volume of gas in the second medical fluid pump prior to its pump-out stroke and to use the calculated volume of gas during its pump-out stroke to determine at least one partial stroke volume of fluid pumped.

12. The medical fluid pumping system of claim 11, the second medical fluid pump connected fluidly to the first pressure chamber and a third pressure chamber, the third pressure chamber connected operably to a third pressure sensor, the processor using a reading from the first pressure sensor to calculate the volume of gas prior to the second pump-out stroke of the second pump and a reading from the third pressure sensor to calculate the partial stroke fluid volume.

13. The medical fluid pumping system of claim 1, wherein the at least one processor is further configured to calculate a volume of gas in the medical fluid pump after the pump-out stroke using a reading from the first pressure sensor after exposing the pump to gas pressure from the first pressure chamber.

14. The medical fluid pumping system of claim 13, wherein the at least one processor is further configured to calculate a total volume of fluid pumped via the pump-out stroke by subtracting the volume of gas in the medical fluid pump after the pump-out stroke from the volume of gas in the medical fluid pump prior to the pump-out stroke.

15. A medical fluid pumping system comprising:

a medical fluid pump;

a first pressure chamber separate from and connected fluidly to the medical fluid pump;

a second pressure chamber separate from and connected fluidly to the medical fluid pump;

first and second pressure sensors connected operably to the first and second pressure chambers, respectively;

at least one processor operable with the pressure sensors to calculate a volume of gas in the medical fluid pump prior to a pump-out stroke using a reading from the first pressure sensor after exposing the pump to gas pressure from the first pressure chamber and to use the calculated volume of gas in combination with a known volume of the second pressure chamber and a pressure decay reading taken via the second pressure sensor during the pump-out stroke to calculate at least one volume of fluid pumped during the pump-out stroke;

wherein the at least one processor is further configured to;

(a) calculate a volume of gas in the medical fluid pump after the pump-out stroke using a reading from the first pressure sensor after exposing the pump to gas pressure from the first chamber; and

(b) calculate a total volume of fluid pumped via the pump-out stroke by subtracting the volume of gas in the medical fluid pump after the pump-out stroke from the volume of gas in the medical fluid pump prior to the pump-out stroke; and

wherein the total volume of fluid pumped via the pump-out stroke is a first total volume, and which includes a second total volume of fluid pumped calculated by the processor using a final pressure decay reading taken via the second pressure senor, the at least one processor further configured to compare the first and second total fluid volumes pumped via the pump-out stroke.

32. The medical fluid pumping system of claim 15, wherein the comparison of the first and second total volumes pumped is used in at least one pumping procedure selected from the group consisting of:

(i) determining if a line occlusion has occurred;

(ii) determining if air is present in the system;

(iii) determining fluid flowrate; and

(iv) determining if dialysis fluid components have been mixed properly.

16. A medical fluid pumping system comprising:

a medical fluid pump;

a pressure chamber connected fluidly to the medical fluid pump;

a pressure sensor connected operably to the pressure chamber; and

at least one processor operable with the pressure sensor to calculate at least one volume of fluid pumped during a pump-out stroke V_fluid,t according to an equation

V_fluid,t=(P_{press, initial}/P_press,t−

1)(V_press+V_gas), wherein

(i) P_{press,initial} is an initial pressure of the pressure chamber prior to the pump-out stroke;

(ii) P_press,t is a pressure of the pressure chamber at a time t during the pump-out stroke;

(iii) V_press is a known volume of the pressure chamber; and

(iv) V_gas is a volume of gas in the medical fluid pump prior to the pump-out stroke.

17. The medical fluid pumping system of claim 16, the pressure chamber a first pressure chamber, the pressure sensor a first pressure sensor and which includes a second pressure chamber and a second pressure sensor operable with the second pressure chamber, and wherein V_gas is determined using a reading from the second pressure sensor after exposing the pump to gas pressure from the second pressure chamber prior to the pump-out stroke.

18. The medical fluid pumping system of claim 17, the processor further configured to calculate a total volume of fluid pumped using V_gas and a final volume of air in the pressure chamber using a final reading from the second pressure sensor after exposing the pump to gas pressure from the second pressure chamber after the pump-out stroke.

19. The medical fluid pumping system of claim 18, wherein the total volume of fluid pumped via the pump-out stroke is a first total volume, and which includes a second total volume of fluid pumped calculated by the processor using a final pressure decay reading taken via the first pressure senor, the at least one processor further configured to compare the first and second total fluid volumes pumped via the pump-out stroke.

20. The medical fluid pumping system of claim 19, wherein the comparison of the first and second total volumes pumped is used in at least one pumping procedure selected from the group consisting of:

(i) determining if a line occlusion has occurred;

(ii) determining if air is in the system;

(iii) determining fluid flowrate; and

(iv) determining if dialysis fluid components have been mixed properly.

21. The medical fluid pumping system of claim 16, wherein the medical fluid pump is exposed to gas pressure from the pressure chamber to perform the pump-out stroke.

22. The medical fluid pumping system of claim 16, the pressure chamber a first pressure chamber, the pressure sensor a first pressure sensor, which includes a second pressure chamber and a second pressure sensor operable with the second pressure chamber, and which includes a reference chamber connected fluidly to the medical fluid pump, and wherein the at least one processor is configured to calculate V_gas according to an equation

V_gas=(P_{ref, final}−

P_{ref, initial})/(P_{press1, initial}−

P_{press1, final})*V_ref, wherein

(i) P_ref,final is a final pressure in the reference chamber after the medical fluid pump is exposed to gas pressure from the second pressure chamber;

(ii) P_ref,initial is an initial pressure in the reference chamber before the medical fluid pump is exposed to gas pressure from the second pressure chamber;

(iii) P_{press1, initial} is an initial pressure in the second pressure chamber before the medical fluid pump is exposed to gas pressure from the second pressure chamber;

(iv) P_{press1, final} is a final pressure in the second pressure chamber after the medical fluid pump is exposed to gas pressure from the first pressure chamber; and

(v) V_ref is the volume of the reference chamber.

23. The medical fluid pumping system of claim 16, the at least one processor configured to calculate a flowrate by subtracting a volume V_fluid,t at a first time from a volume V_fluid,t at a second time and dividing the difference by the time period from the first time to the second time.

24. A medical fluid pumping system comprising:

a medical fluid pump;

a pressure chamber connected fluidly to the medical fluid pump;

a pressure sensor connected operably to the pressure chamber; and

at least one processor operable with the pressure sensor to calculate at least one volume of fluid pumped during a pump-fill stroke V_fluid,t according to an equation

V_fluid,t=(P_{press, initial}/P_press,t−

1)(V_press+V_gas), wherein

(i) P_{press,initial} is an initial negative pressure of the pressure chamber prior to the pump-fill stroke;

(ii) P_press,t is a negative pressure of the pressure chamber at a time t during the pump-fill stroke;

(iii) V_press is a known volume of the pressure chamber; and

(iv) V_gas is a volume of gas in the medical fluid pump under negative pressure prior to the pump-fill stroke.

25. The medical fluid pumping system of claim 24, the pressure chamber a first pressure chamber, the pressure sensor a first pressure sensor, which includes a second pressure chamber and a second pressure sensor operable with the second pressure chamber, and wherein V_gas is determined using a negative pressure reading from the second pressure sensor after exposing the pump to negative gas pressure from the second pressure chamber prior to the pump-fill stroke.

26. The medical fluid pumping system of claim 25, the processor further configured to calculate a total volume of fluid pumped using V_gas and a final volume of air in the pressure chamber using a final negative pressure reading from the second pressure sensor after exposing the pump to negative gas pressure from the second pressure chamber after the pump-fill stroke.

27. The medical fluid pumping system of claim 26, wherein the total volume of fluid pumped via the pump-fill stroke is a first total volume, and which includes a second total volume of fluid pumped calculated by the processor using a final negative pressure decay reading taken via the first pressure senor, the at least one processor further configured to compare the first and second total fluid volumes pumped via the pump-fill stroke.

28. The medical fluid pumping system of claim 27, wherein the comparison of the first and second total volumes pumped is used in at least one pumping procedure selected from the group consisting of:

(i) determining if a line occlusion has occurred;

(ii) determining if air is in the system; and

(iii) determining fluid flowrate.

29. The medical fluid pumping system of claim 24, wherein the medical fluid pump is exposed to negative gas pressure from the pressure chamber to perform the pump-fill stroke.

30. The medical fluid pumping system of claim 24, the pressure chamber a first pressure chamber, the pressure sensor a first pressure sensor, which includes a second pressure chamber and a second pressure sensor operable with the second pressure chamber, and which includes a reference chamber connected fluidly to the medical fluid pump, and wherein the at least one processor is configured to calculate V_gas according to an equation

V_gas=(P_{ref, final}−

P_{ref, initial})/(P_{press1, initial}−

P_{press1, final})*V_ref, wherein

(i) P_ref,final is a final negative pressure in the reference chamber after the medical fluid pump is exposed to negative gas pressure from the second pressure chamber;

(ii) P_ref,initial is an initial pressure in the reference chamber before the medical fluid pump is exposed to negative gas pressure from the second pressure chamber;

(iii) P_{press1, initial} is an initial negative pressure in the second pressure chamber before the medical fluid pump is exposed to negative gas pressure from the second pressure chamber;

(iv) P_{press1, final} is a final negative pressure in the second pressure chamber after the medical fluid pump is exposed to negative gas pressure from the first pressure chamber; and

(V) V_ref is the volume of the reference chamber.

31. The medical fluid pumping system of claim 24, the at least one processor configured to calculate a flowrate by subtracting a volume V_fluid,t at a first time from a volume V_fluid,t at a second time and dividing a resulting difference by a time period from the first time to the second time.