Micromachined bilayer unit for filtration of small molecules
First Claim
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1. An apparatus for the filtration of small molecules, comprisinga) first polymer substrate, wherein the first polymer substrate comprises a microvascular network for circulation of fluid longitudinally through the first polymer substrate, the microvascular network comprised of acellular microchannels that are about 5 μ
- m to about 100 μ
m in height, and that begin at one or more inlets, serially branch into a large array of microchannels, and then converge back into one or more microchannels at one or more outlets;
b) a second polymer substrate, wherein the second polymer substrate comprises acellular fluidic chambers; and
c) a semi-permeable membrane disposed between the first and second polymer substrates;
wherein the first and second polymer substrates are fastened together about the semi-permeable membrane, and,wherein small molecules are filtered from fluid in the microvascular network of the first polymer substrate through the semi-permeable membrane to the acellular fluidic chambers of the second polymer substrate.
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Abstract
Methods and materials for making an apparatus which duplicates the functionality of a physiological system id provided.
143 Citations
6 Claims
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1. An apparatus for the filtration of small molecules, comprising
a) first polymer substrate, wherein the first polymer substrate comprises a microvascular network for circulation of fluid longitudinally through the first polymer substrate, the microvascular network comprised of acellular microchannels that are about 5 μ - m to about 100 μ
m in height, and that begin at one or more inlets, serially branch into a large array of microchannels, and then converge back into one or more microchannels at one or more outlets;b) a second polymer substrate, wherein the second polymer substrate comprises acellular fluidic chambers; and c) a semi-permeable membrane disposed between the first and second polymer substrates; wherein the first and second polymer substrates are fastened together about the semi-permeable membrane, and, wherein small molecules are filtered from fluid in the microvascular network of the first polymer substrate through the semi-permeable membrane to the acellular fluidic chambers of the second polymer substrate. - View Dependent Claims (2, 3, 4, 5, 6)
- m to about 100 μ
Specification
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Current AssigneeCharles Stark Draper Laboratory Incorporated, Massachusetts Institute of Technology, The General Hospital Corporation (Mass General Brigham, Inc.)
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Original AssigneeCharles Stark Draper Laboratory Incorporated, Massachusetts Institute of Technology, The General Hospital Corporation (Mass General Brigham, Inc.)
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InventorsOrrick, Brian K., Borenstein, Jeffrey T., Barnard, Edward J., Kaazempur-Mofrad, Mohammad Reza, Vacanti, Joseph P., Krebs, Nicholas J., Pritchard, Eleanor M., Weinberg, Eli, Marentis, Theodore
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Primary Examiner(s)Ford; Allison M.
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Application NumberUS10/983,213Publication NumberTime in Patent Office2,111 DaysField of SearchNoneUS Class Current604/406CPC Class CodesA61M 1/1678 intracorporal peritoneal di...Y10T 436/25375 Liberation or purification ...Y10T 436/255 including use of a solid so...
