Dialysis system

• US 7,776,210 B2
• Filed: 06/09/2005
• Issued: 08/17/2010
• Est. Priority Date: 06/09/2004
• Status: Expired due to Fees

• Current Assignee: Renal Solutions, Inc. (Fresenius Medical Care AG)
• Original Assignee: Renal Solutions, Inc. (Fresenius Medical Care AG)
• Inventors: Rosenbaum, Benjamin P, Carr, David J., Ash, Stephen R.
• Primary Examiner(s): Kim; Vickie
• Assistant Examiner(s): BASS, DIRK R
• Application Number:
  US11/148,928
• Publication Number:
  US 20050274658A1
• Time in Patent Office: 1,895 Days
• Field of Search: 210/646, 210/96.2, 210/321.71, 210/259, 210/266, 210/130, 210/433.1
• US Class Current: 210/96.2
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/3403 Regulation parameters
• CPC Class Codes: A61M 1/341 by measuring the filtrate rate or volume
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation

Abstract

A dialysate fluid circulation apparatus includes a dialyzer, a first housing and a second housing. The first housing contains material capable of releasing sodium into dialysate fluid flowing through the first housing. The second housing contains material capable of binding sodium ions from dialysate fluid flowing through the second housing. Hydraulic conduit sections are configured to extend between the dialyzer, the first housing, and the second housing to connect the dialyzer with the housings in a primary flow path for dialysate fluid to flow from the dialyzer to the first housing, from the first housing to the second housing, and from the second housing back to the dialyzer.

Claims

1. A dialysate fluid circulation apparatus comprising:

(a) a dialyzer;

(b) a first housing containing material capable of releasing sodium into dialysate fluid flowing through the first housing;

(c) a second housing containing material capable of binding sodium ions from dialysate fluid flowing through the second housing;

(d) hydraulic conduit sections configured to extend between the dialyzer, the first housing, and the second housing to connect the dialyzer with the first and second housings in a primary flow path for dialysate fluid to flow from the dialyzer to the first housing, from the first housing to the second housing, and from the second housing back to the dialyzer; and

(e) hydraulic conduit sections configured to define a bypass flow path, the bypass flow path providing a flow path for dialysate fluid to bypass the second housing by flowing from the first housing back to the dialyzer.

2. The apparatus of claim 1, further comprising a fluid flow regulator operative to control flows of dialysate fluid along the primary and bypass flow paths.

3. The apparatus of claim 2, further comprising a meter operative to indicate the sodium ion concentration in the dialysate fluid emerging from the first housing.

4. The apparatus of claim 3, further comprising a controller that is operatively interconnected with the regulator and the meter to actuate the regulator in response to the sodium ion concentration indicated by the meter.

5. The apparatus of claim 1, further comprising a volumetric ultrafiltration apparatus, including a hydraulic conduit, a fluid flow regulator, and a fluid receptacle in fluid flow communication with the dialyzer.

6. The apparatus of claim 1, wherein the dialyzer, the first housing, the second housing, and the hydraulic conduit sections are interconnected parts of a dialysate fluid circulation system having a non-expandable volume.

7. The apparatus of claim 6, wherein the non-expandable volume is less than or equal to about 3 liters.

8. The apparatus of claim 6, wherein the non-expandable volume is less than or equal to about 2 liters.

9. The apparatus of claim 6, wherein the non-expandable volume is less than or equal to about 1.5 liters.

10. The apparatus of claim 6, wherein the non-expandable volume is about 1 liter.

11. The apparatus of claim 1, wherein the material contained in the second housing comprises mixed bed ion exchange resin.

12. The apparatus of claim 11, wherein the mixed bed ion exchange resin has a sodium ion binding capacity less than or equal to about 800 mEq.

13. The apparatus of claim 11, wherein the mixed bed ion exchange resin has a sodium ion binding capacity less than or equal to about 600 mEq.

14. The apparatus of claim 11, wherein the mixed bed ion exchange resin has a sodium ion binding capacity less than or equal to about 500 mEq.

15. The apparatus of claim 11, wherein the mixed bed ion exchange resin comprises a cation exchange resin and an anion exchange resin.

16. The apparatus of claim 15, wherein the cation exchange resin is a sulfonated spherical styrene divinyl benzene copolymer.

17. The apparatus of claim 15, wherein the anion exchange resin is a spherical quaternary amine styrene divinyl benzene copolymer.

18. An apparatus for use with a dialysate fluid system comprising:

(a) a first housing containing material capable of releasing sodium into dialysate fluid flowing through the first housing;

(b) a second housing containing material capable of binding sodium ions from dialysate fluid flowing through the second housing;

(c) hydraulic conduit sections configured to define a primary flow path, the primary flow path providing a flow path into the first housing, a flow path between the first housing and the second housing, and a flow path exiting the second housing;

(d) hydraulic conduit sections configured to define a bypass flow path, the bypass flow path providing a flow path connecting the primary flow path between the first housing and the second housing to the primary flow path exiting the second housing; and

(e) a fluid flow regulator operative to control flows of dialysate fluid along the primary and bypass flow paths.

19. The apparatus of claim 18, wherein the material contained in the second housing is a mixed bed ion exchange resin.

20. The apparatus of claim 19, wherein the mixed bed ion exchange resin comprises a cation exchange resin and an anionic exchange resin.

21. The apparatus of claim 20, wherein the cation exchange resin is a sulfonated spherical styrene-divinyl benzene copolymer.

22. The apparatus of claim 20, wherein the anion exchange resin is a spherical quaternary amine styrene-divinyl benzene copolymer.

23. The apparatus of claim 19, wherein the mixed bed ion exchange resin has a sodium ion binding capacity of less than or equal to about 800 mEq.

24. The apparatus of claim 19, wherein the mixed bed ion exchange resin has a sodium ion binding capacity of less than or equal to about 600 mEq.

25. The apparatus of claim 19, wherein the mixed bed ion exchange resin has a sodium ion binding capacity of less than or equal to about 500 mEq.

26. The apparatus of claim 18, further comprising a meter operative to indicate the sodium ion concentration in the dialysate fluid emerging from the first housing.

27. The apparatus of claim 26, further comprising a controller that is operatively interconnected with the regulator and the meter to actuate the regulator in response to the sodium ion concentration indicated by the meter.