Metallic structures incorporating bioactive materials and methods for creating the same
First Claim
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1. A method comprising:
- creating a template on a surface of a substrate;
providing a solution comprising metal ions and at least one bioactive material;
contacting said substrate with said solution;
forming a bioactive composite structure on portions of said substrate not covered by said template using an electrochemical process selected from a electrodeposition process, an electrocodeposition process, an electroless deposition process and an electroless codeposition process;
removing said template from said substrate after said formation of said bioactive composite structure thus leaving pores in said structure; and
loading said at least one bioactive material into said pores thus forming a bioactive composite structure over said substrate.
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Abstract
Disclosed herein are methods to create medical devices and medical devices including bioactive composite structures. The methods include using template-assisted electro- or electroless deposition or codeposition methods for providing implantable medical devices coated with bioactive composite structures and also include layering deposited or codeposited metal layers with layers of bioactive materials. In one use, the implantable medical devices of the present invention include stents with bioactive composite structure coatings.
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Citations
8 Claims
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1. A method comprising:
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creating a template on a surface of a substrate; providing a solution comprising metal ions and at least one bioactive material; contacting said substrate with said solution; forming a bioactive composite structure on portions of said substrate not covered by said template using an electrochemical process selected from a electrodeposition process, an electrocodeposition process, an electroless deposition process and an electroless codeposition process; removing said template from said substrate after said formation of said bioactive composite structure thus leaving pores in said structure; and loading said at least one bioactive material into said pores thus forming a bioactive composite structure over said substrate. - View Dependent Claims (2, 3)
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4. A method comprising:
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providing a first solution comprising metal ions; contacting a substrate with said first solution; forming a first metal layer on said substrate using an electrochemical process; applying at least one bioactive material to said first metal layer such that said at least one bioactive material is contained at least in part with said first metal layer; contacting said substrate with said first solution or a second solution; forming a second layer metal layer on said substrate using an electrochemical process. - View Dependent Claims (5, 6, 7, 8)
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Specification