Magnetic resonance coil system

• US 7,777,491 B2
• Filed: 04/28/2008
• Issued: 08/17/2010
• Est. Priority Date: 05/05/2006
• Status: Active Grant

• Current Assignee: Polarean Imaging Ltd.
• Original Assignee: M2M Imaging Corp. (Polarean Imaging Plc)
• Inventors: James, Timothy W., Hullihen, C. Richard III, Devries, Jon T., Kunimoto, Wallace Y., Gao, Erzhen
• Primary Examiner(s): Arana; Louis M
• Application Number:
  US12/110,441
• Publication Number:
  US 20080204028A1
• Time in Patent Office: 841 Days
• Field of Search: 324/318, 324/322
• US Class Current: 324/318
• CPC Class Codes: G01R 33/307 specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
• CPC Class Codes: G01R 33/34023 Superconducting RF coils
• CPC Class Codes: G01R 33/34046 Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils

Abstract

A magnetic resonance coil system 18 allows for the use of modular components and which in one embodiment is particularly well-suited for use with small animals and includes an animal receiving apparatus 202, a transmit coil module 204, and a receive coil module 206. The receive coil module 206 includes a cryogenic receive coil. The coil system 18 is selectively insertable in the bore of the gradient coil of a magnetic resonance examination system.

Claims

1. A modular coil system for use with a magnetic resonance imaging device, comprising:

a radio frequency cryogenic coil that excites magnetic resonance in nuclei and receives a magnetic resonance signal from excited nuclei, wherein the radio frequency cryogenic coil is operated at a cryogenic temperature during the excitation of the magnetic resonance in the nuclei and the reception of the magnetic resonance signals;

a sample receiving region that supports a sample being imaged during the magnetic resonance procedure; and

a cooling system that maintains a temperature of the radio frequency cryogenic coil within a cryogenic temperature range wherein the cooling system includes a cold head and the radio frequency cryogenic coil is disposed on a coil holder contacting the cold head such that the radio frequency cryogenic coil is in thermal communication with the cold head;

wherein the radio frequency cryogenic coil and the sample receiving region are selectively removeably assembleable to form the modular coil system.

2. The system of claim 1, wherein the cooling system includes a cryocooler.

3. The system of claim 1, wherein the magnetic resonance system is a small animal magnetic resonance scanner.

4. The system of claim 1, wherein the radio frequency cryogenic coil comprises electrical circuitry that includes at least one of decoupling circuitry, a quadrature combiner, and a preamplifier.

5. The system of claim 1, further including an openable cover that closes to cover the sample receiving region, thereby mitigating contamination of an animal sample supported by the sample receiving region.

6. The system of claim 1, wherein the radio frequency cryogenic coil generates a signal that includes sample noise and coil noise, and the sample noise predominates over the coil noise.

7. The system of claim 1, wherein the radio frequency cryogenic coil includes:

a cryogenic region;

a thermally reflective radiation barrier disposed between the cryogenic region and the ambient environment, wherein the thermally reflective radiation barrier is substantially RF transparent;

an evacuated region; and

a hermetically sealed, non-magnetic electrical feedthrough extending between the evacuated region and the ambient environment.

8. The system of claim 1, wherein the module includes a variable reactor, a rotating shaft operatively connected to the variable reactor for varying reactance, and a clutch operatively connected to the rod, wherein the clutch slips when the variable rector reaches an end of travel, and wherein the variable reactor tunes the radio frequency cryogenic coil.

9. The system of claim 1, wherein the modular coil system is selectively insertable in an examination region of the magnetic resonance imaging device for conducting a magnetic resonance examination of the sample.

10. The system of claim 1, wherein the cold head and the coil holder are separate components from each other.

11. A method, comprising:

transmitting, by a cryogenic transmit coil, an excitation radio frequency signal to excite nuclei in a subject during a magnetic resonance examination of the subject with a small animal magnetic resonance imaging system, wherein the cryogenic transmit coil is operated at a cryogenic temperature during the excitation magnetic resonance in the nuclei;

receiving, by a cryogenic receive coil, a magnetic resonance signal emitted by the excited nuclei, wherein the cryogenic receive coil is operated at a cryogenic temperature during the reception of the magnetic resonance signals; and

cooling with a cooling system the cryogenic transmit and receive coils to maintain the cryogenic transmit and receive coils within a cryogenic temperature range, wherein the cooling system includes a cold head and the cryogenic transmit and receive coils are disposed on a coil holder contacting the cold head such that the cryogenic transmit and receive coils are in thermal communication with the cold head;

wherein the cryogenic transmit coil and the cryogenic receive coil are removeable components of a modular coil system that inserts into an examination region of a magnetic resonance scanner.

12. The method of claim 11, further including cooling the cryogenic receive coil to the cryogenic temperature by introducing a cryogen into a dewar in thermal communication with the cryogenic receive coil.

13. The method of claim 11, further including cooling the cryogenic receive coil to the cryogenic temperature using a cryocooler.

14. The method of claim 11, wherein the cryogenic receive coil and the transmit coil are independent and distinct components of the modular coil system and are separately removeable from the modular coil system.

15. The method of claim 11, wherein the modular coil system includes a subject support that supports the subject during the examination, and the modular coil system is configured to be removed from the small animal magnetic resonance imaging system for insertion and removal of the subject from the subject support.

16. The method of claim 11, further including tuning the transmit coil to a desired frequency range.

17. The method of claim 11, further including heating a subject receiving region supporting the subject during the examination.

18. A modular magnetic resonance radio frequency coil module, comprising:

means for supporting a sample in the module;

cryogenic means for transmitting an excitation radio frequency signal to excite nuclei in the sample, wherein the cryogenic means for transmitting is operated at a cryogenic temperature during the excitation of magnetic resonance in the nuclei;

cryogenic means for receiving a magnetic resonance signal emitted from the excited nuclei, wherein the cryogenic means for receiving the magnetic resonance signal is operated at a cryogenic temperature during the reception of the magnetic resonance signals; and

means for cryogenically cooling the cryogenic means for transmitting and the cryogenic means for receiving to a cryogenic temperature, wherein the means for cryogenically cooling includes a cold head and the cryogenic means for transmitting and receiving are disposed on a coil holder contacting the cold head such that the cryogenic means for transmitting and receiving are in thermal communication with the cold head.

19. The modular magnetic resonance radio frequency coil module of claim 18, further including means for removeably attaching the means for transmitting and the cryogenic means for receiving together to form a single module.

20. The module of claim 18, wherein the means for supporting the sample and cryogenic means for transmitting and receiving are removeable components of the modular magnetic resonance frequency coil module that inserts into an examination region of a magnetic resonance scanner.