Detection of ischemia

• US 7,778,697 B2
• Filed: 10/11/2004
• Issued: 08/17/2010
• Est. Priority Date: 10/11/2004
• Status: Expired due to Fees

• Current Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Inventors: Norén, Kjell, Björling, Anders
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): MORALES, JON ERIC C
• Application Number:
  US11/667,505
• Publication Number:
  US 20090143690A1
• Time in Patent Office: 2,136 Days
• Field of Search: 600/509, 600/508, 600/507
• US Class Current: 600/509
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

In an ischemia detection method, and in an ischemia detector and a cardiac stimulator embodying an ischemia detector, a workload of a patient is measured, as is an ejection fraction (EF) associated with the heart of the patient is determined. A predetermined reference relation between EF and workload for the patient is stored, and an analysis unit detects a state of ischemia of the patient from deviation in the determined EF for various workloads from the stored reference relation.

Claims

1. An ischemia detector comprising:

a workload sensor configured to interact with a patient to sense a workload of the patient;

an ejection fraction (EF) determining unit that determines an ejection fraction associated with the heart of the patient;

a storage unit that stores a predetermined reference relation between EF and workload for the patient; and

an analyzing unit that identifies a state of ischemia of the patient dependent on a deviation of EF determined by said EF determining unit for respective workloads of the patient from the stored reference relation.

2. An ischemia detector as claimed in claim 1 wherein said EF determining unit comprises an EF sensor that senses a parameter representative of EF, and a calculation unit that calculates EF for the patient from said parameter.

3. An ischemia detector as claimed in claim 1 wherein said EF sensor is a CMES sensor.

4. An ischemia detector as claimed in claim 1 wherein said EF sensor is a pressure sensor.

5. An ischemia detector as claimed in claim 1 wherein said EF sensor is a photo-plethysmograph.

6. An ischemia detector as claimed in claim 1 wherein said EF sensor is an impedance measuring arrangement configured to measure an impedance across the heart of the patient.

7. An ischemia detector as claimed in claim 6 wherein said impedance measuring arrangement comprises leads configured for implantation into the heart of the patient.

8. An ischemia detector as claimed in claim 1 wherein said workload sensor comprises an accelerometer.

9. An ischemia detector as claimed in claim 1 wherein said workload sensor comprises an arrangement for determining minute ventilation of the patient.

10. An ischemia detector as claimed in claim 1 wherein said workload sensor comprises a P-wave rate detector.

11. An ischemia detector as claimed in claim 1 wherein said workload sensor comprise an arrangement that determines metabolic demand of the patient.

12. An ischemia detector as claimed in claim 1 wherein said analyzing unit comprises a quotient forming unit that forms a quotient between a change in EF and a corresponding change in the workload, and a quotient comparator that compares said quotient with a predetermined quotient reference value.

13. An ischemia detector as claimed in claim 1 comprising a derivative former that determines a derivative of EF with respect to said workload, and a derivative comparator that compares said derivative with a predetermined derivative reference value.

14. An ischemia detector as claimed in claim 1 comprising a circular buffer that stores a predetermined number of analysis results from said analyzing unit.

15. An ischemia detector as claimed in claim 1 wherein said EF determining unit identifies an onset of QRS and opening and closing of the aortic valve of the heart of the patient.

16. An ischemia detector as claimed in claim 15 wherein said EF determining unit determines left ventricular ejection fraction (LEVF) from an equation selected from the group consisting of

LVEF=0.84−

0.64*PEP/LVET

LVEF=1.125−

1.25*PEP/LVET

wherein PEP is a pre-ejection period from said onset of QRS to said opening of the aortic valve, and LVET is a left ventricular ejection time from said opening of the aortic valve to said closing of the aortic valve.

17. An ischemia detector as claimed in claim 1 comprising an alerting unit that emits an output signal in response to detection of said state of ischemia by said analyzing unit.

18. A heart stimulator comprising:

an ischemia detector comprising a workload sensor configured to interact with a patient to sense a workload of the patient,

an ejection fraction (EF) determining unit that determines an ejection fraction associated with the heart of the patient, a storage unit that stores a predetermined reference relation between EF and workload for the patient, and an analyzing unit that identifies a state of ischemia of the patient dependent on a deviation of EF determined by said EF determining unit for respective workloads of the patient from the stored reference relation;

a stimulation pulse delivery arrangement configured to deliver stimulation pulses to the heart of the patient; and

a control unit connected to said ischemia detector and to said stimulation pulse delivery arrangement that controls deliver of said stimulation pulses to the patient by said stimulation pulse delivery arrangement dependent on detection of said state of ischemia by said analyzing unit of said ischemia detector.

19. A heart stimulator as claimed in claim 18 comprising a stimulator housing, and wherein said stimulation pulse delivery arrangement comprises a bipolar right ventricular lead having a tip electrode and a ring electrode, and a left ventricular lead having a tip electrode, and wherein said EF determining unit of said ischemia detector comprises an impedance measuring arrangement that includes said bipolar right ventricular lead and said left ventricular lead, and a current source that supplies a current between the tip electrode of the right ventricular lead and said stimulator housing, and a voltage measuring arrangement that measures a voltage, resulting from said current, between said ring electrode of said right ventricular lead and said tip electrode of said left ventricular lead.

20. A heart stimulator as claimed in claim 18 wherein said stimulation pulse delivery arrangement comprises a bipolar right ventricular lead having a tip electrode and a ring electrode, and a bipolar left ventricular lead having a tip electrode and a ring electrode, and wherein said EF determining unit of said ischemia detector comprises an impedance measuring arrangement that includes said bipolar right ventricular lead and said bipolar left ventricular lead, and a current source that applies a current between the tip electrode of the right ventricular lead and the ring electrode of the left ventricular lead, and a voltage measuring arrangement that measures a voltage, resulting from said current, between the ring electrode of the right ventricular lead and the tip electrode of the left ventricular lead.

21. A method for detecting a state of ischemia of a patient comprising the steps of:

detecting a parameter indicative of ejection fraction (EF) of the heart of the patient;

detecting a parameter indicative of workload of the patient;

identifying a predetermined reference relation between EF and workload for the patient; and

detecting a state of ischemia of the patient from deviations in EF for respective workloads from said predetermined reference relation.

22. A method as claimed in claim 21 comprising forming a quotient between a change in EF and a corresponding change in said workload, and comparing said quotient with a predetermined quotient reference value.

23. A method as claimed in claim 21 comprising forming a derivative of EF with respect to workload, and comparing said derivative with a predetermined derivative reference value.

24. A method as claimed in claim 21 comprising determining onset of QRS and opening and closing of the aortic value of the heart of the patient, and calculating left ventricular ejection fraction (LVEF) from an equation selected from the group consisting of

LVEF=0.84−

0.64*PEP/LVET

LVEF=1.125−

1.25*PEP/LVET

wherein PEP is a pre-ejection period from said onset of QRS to said opening of the aortic valve, and LVET is a left ventricular ejection time from said opening of the aortic valve to said closing of the aortic valve.

25. A method as claimed in claim 21 comprising storing an occurrence of detection of said state of ischemia of the patient in a data base, accessible for subsequent analysis.