Method and device for using impedance measurements based on electrical energy of the heart

• US 7,778,709 B2
• Filed: 04/11/2005
• Issued: 08/17/2010
• Est. Priority Date: 10/01/2001
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Gollasch, Maik, Alt, Eckhard
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US11/104,389
• Publication Number:
  US 20050288726A1
• Time in Patent Office: 1,954 Days
• Field of Search: 607/17, 607/35, 607/9, 607/34
• US Class Current: 607/35
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A method and a device are disclosed for evaluating the cardio-circulatory and pulmonary condition of a patient, including determining the patient'"'"'s thoracic impedance based on information solely derived from the electrical energy generated by the patient'"'"'s own heart.

Claims

1. A method of evaluating a condition of a patient having a heart and a thoracic impedance, comprising the steps of:

detecting an electrical signal from said heart of said patient using signal circuitry via electrode means arranged and adapted for sensing said electrical signal, while using electrical energy generated by said heart of said patient and no other electrical power for said signal circuitry; and

determining said thoracic impedance based on said electrical signal.

2. The method as in claim 1 further comprising the step of optimizing a function of a rate adaptive pacemaker based, at least in part, of said thoracic impedance.

3. The method as in claim 1 further comprising the step of optimizing monitoring of a congestive heart failure of said patient based, at least in part, of said thoracic impedance.

4. The method as in claim 1 wherein said electrical signal is at least partially representative of an EKG of said patient.

5. The method as in claim 4 wherein said EKG is sensed on an intracardiac basis.

6. The method as in claim 5 wherein said detecting step is accomplished, at least in part, by a bipolar electrode.

7. The method as in claim 5 wherein said detecting step is accomplished, at least in part, by a unipolar electrode.

8. The method as in claim 7 wherein said detecting step is accomplished, at least in part, with a device adapted to be implanted in said patient, wherein said detecting step utilizes one electrode positioned in said heart of said patient and electrically connected to circuitry within an implanted device and another electrode constituting an electrically conductive portion of a case of said device.

9. The method as in claim 4 wherein said detecting step utilizes a device adapted to be implanted in said patient and utilizes surface mounted electrodes associated with said device.

10. The method as in claim 4 wherein said detecting step senses from said electrical signal two EKG derived information signals reflecting relatively high and low input impedance loads on said electrode means.

11. The method as in claim 10 wherein said determining step processes said two EKG derived information signals to obtain information indicative of short-term and long-term trends of said thoracic impedance of said patient.

12. The method as in claim 1 wherein said thoracic impedance comprises impedance from myocardial tissue, fibrous connective tissue in the heart, pericardium, blood within the heart, fluids within the intracellular spaces, and the surrounding environment of connective tissue atria, pulmonary structures, venous structures, and lung tissue.

13. A method of adjusting a heart rate of a patient having a heart and thoracic impedance by means of an implantable rate adaptive pacemaker having a pacing rate, comprising the steps of:

determining said thoracic impedance from said heart of said patient using signal circuitry while using electrical energy generated by said heart of said patient and no other electrical power for said signal circuitry;

adjusting said pacing rate of said implantable rate adaptive pacemaker in response to said thoracic impedance.

14. The method as in claim 13 further comprising the step optimizing said pacing rate through closed loop optimization.

15. The method as in claim 13 further comprising the step of adapting a heart rate of a rate adaptive pacemaker based, at least in part, on said thoracic impedance.

16. The method as in claim 13 further comprising the step of instantaneously influencing adaptation of said pacing rate on an ongoing basis within minutes based, at least in part, on said intrinsic impedance.

17. The method as in claim 13 further comprising the step of determining said adaptation of said pacing rate on a long term daily and/or monthly basis based, at least in part, on long term rate and cardio-circulatory response from said intrinsic impedance information of said patient.

18. A method of monitoring a cardio-circulatory status of a patient having a heart and a thoracic impedance with an implantable device, comprising the steps of:

detecting an electrical signal from said heart of said patient using signal circuitry while using electrical energy generated by said heart of said patient and no other electrical power for said signal circuitry; and

calculating said impedance based on said electrical signal.

19. The method as in claim 18 wherein said detecting step is accomplished subcutaneously.

20. The method as in claim 18 wherein said electrical signal is at least partially representative of an EKG of said patient and wherein said calculating step is at least partially accomplished through differential signal processing of said electrical signal.

21. The method as in claim 20 further comprising the step of applying information concerning changes in said impedance to determine said cardio-circulatory status of said patient.

22. The method as in claim 18, wherein the patient is suffering from heart failure, further comprising the step of monitoring said heart failure by performing said calculating step in calculating said impedance.

23. A method of enhancing function of a body-implantable defibrillator having sensing electrodes adapted to function in conjunction with a heart of a patient, comprising the steps of:

detecting an electrical signal generated by said heart of said patient using signal circuitry while using electrical energy generated by said heart of said patient and no other electrical power for said signal circuitry; and

determining an impedance between said sensing electrodes of said defibrillator based, at least in part, on said electrical signal; and

determining changes in said impedance between said sensing electrodes of said defibrillator based, at least in part, on said electrical signal.

24. A device for monitoring a cardio-circulatory status of a patient having a heart and a thoracic impedance with an implantable device comprising:

signal circuitry means for detecting an electrical signal generated by said heart of said patient while using electrical energy generated by said heart of said patient and no other electrical power for said signal circuitry means; and

means for calculating said thoracic impedance based on said electrical signal.

25. A method of obtaining information about a cardiac function of a patient having a heart, comprising the steps of:

detecting an electrical signal generated by said heart of said patient related to an EKG using signal circuitry while using electrical energy generated by said heart of said patient and no other electrical power for said signal circuitry; and

continuously processing said electrical signal during depolarization and repolarization of said heart of said patient, said electrical signal representing systole and diastole as different phases of said heart.

26. The method as in claim 25 further comprising the steps of:

analyzing an impedance of said heart and changes of said impedance with systole from a point close to a T-Wave of said electrical signal; and

deriving information on a diastolic status of said heart derived from said electrical signal close to an R-Wave of said electrical signal.

27. The method as in claim 26 further comprising the step of comparing said impedance at systole with said impedance at diastole to assess a cardio-circulatory status of said patient.

28. An implantable medical device for monitoring a cardio-pulmonary status of a patient having a heart and a thoracic impedance, comprising:

signal circuitry means for detecting an electrical signal generated by said heart of said patient related to an EKG while using electrical energy generated by said heart of said patient and no other electrical power for said signal circuitry means; and

means for determining said thoracic impedance based on said electrical signal related to said EKG.

29. The implantable medical device of claim 28, wherein said implantable medical device is adapted for subcutaneous implantation.

30. An implantable device as in claim 28 for monitoring a cardio-pulmonary status of a patient having a heart, comprising means for determining a thoracic impedance of said patient from an EKG signal information acquired using electrical energy generated by said heart of said patient;

and

surface mounted electrodes, operatively coupled to said means for determining, for sensing said EKG signal information;

wherein said device is adapted for subcutaneous implantation.

31. The implantable medical device as in claim 28 further comprising signal processing means, operatively coupled to said means for determining, for deriving information concerning changes in said thoracic impedance to determine the cardio-pulmonary status of the patient.

32. The device of claim 28, wherein said implantable medical device is adapted for cardiac pacing, and further comprising means for negative feedback closed loop control of said cardiac pacing for optimization of a pacing rate to match a fitness level of said patient engaged in physical activity.