Ventilator breath condensate sampler and method of collecting a breath condensate sample

• US 7,779,840 B2
• Filed: 06/21/2006
• Issued: 08/24/2010
• Est. Priority Date: 06/21/2006
• Status: Active Grant

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Acker, Jaron M., Bilek, Kristopher J.
• Primary Examiner(s): DEMILLE, DANTON D
• Application Number:
  US11/425,417
• Publication Number:
  US 20080009761A1
• Time in Patent Office: 1,525 Days
• Field of Search: 128/204.15, 128/204.16, 128/104.18, 128/204.21, 128/205.12, 128/206.15, 600/529, 600/532, 600/543
• US Class Current: 128/204.16
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61M 16/0808 Condensation traps
• CPC Class Codes: A61M 16/085 Gas sampling
• CPC Class Codes: A61M 2205/3606 cooled
• CPC Class Codes: A61M 2205/3673 thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors

Abstract

A breath condensate sampler for use with a mechanical ventilator, the breath condensate sampler includes an airflow valve, a condensate formation tube, a condensate trap, and a condensate collection receptacle. The airflow valve directs air from the expiratory limb into the condensate formation tube wherein the condensate portion of exhaled gases are separated from the gaseous portion of the exhaled gases. A method of collecting a breath condensate sample is also herein disclosed.

Claims

1. A method of collecting a sample of breath condensate from a patient receiving mechanical ventilation via a mechanical ventilator, the method comprising the steps of:

inserting a breath condensate sampler in fluid connection with an expiratory limb of the ventilator, the expiratory limb directing exhaled breath away from the patient;

activating the sampler to collect a sample of breath condensate from the exhaled breath;

cooling a condensate formation tube of the breath condensate sampler to a target temperature;

shunting the exhaled breath from the expiratory limb into the condensate formation tube;

condensing breath condensate from the exhaled breath as the exhaled breath passes through the condensate formation tube and back to the expiratory limb;

collecting a breath condensate sample;

ending the breath and condensate sample collection when the breath condensate sample reaches a threshold volume.

2. The method of claim 1 further comprising the step of analyzing the breath condensate sample to determine constituent concentrates of the breath condensate sample.

3. The method of claim 2 wherein collecting the breath condensate sample comprises directing the breath condensate sample into a breath condensate sample analysis device.

4. The method of claim 3 wherein the breath condensate sample analysis device is a mass spectrograph.

5. The method of claim 1 wherein the step of activating the sampler is performed automatically according to a pre-determined schedule of sample collections.

6. The method of claim 1 wherein the threshold volume is between 0.25 mL and 3 mL.

7. A breath condensate sampler for use with a mechanical ventilator delivering respiratory support to a patient via a breathing circuit, the breath condensate sampler comprising:

an air flow valve configured to couple with the breathing circuit and to receive exhaled gases therefrom through an inlet, the air flow valve being movable between a first position that allows exhaled gases to flow from the inlet through the air flow valve and a second position that directs exhaled gases from the inlet into the breath condensate sampler;

a condensate formation tube connected to the air flow valve, the condensate formation tube separates a condensate portion of the exhaled gases from a gaseous portion of the exhaled gases and directs the gaseous portion out of the breath condensate sampler;

a cooling sleeve surrounding at least a portion of the condensate formation tube;

a cooling apparatus coupled to the cooling sleeve such as to cool the cooling sleeve and the condensate formation tube, wherein the condensate formation tube further comprises a thermally conductive material;

a condensate trap connected to the condensate formation tube, the condensate trap collects the condensate portion from the condensate formation tube; and

a condensate collection receptacle connected to the condensate trap, the condensate collection receptacle accumulates the condensate portion of the exhaled gases.

8. The breath condensate sampler of claim 7, wherein the cooling apparatus further comprises a Peltier device and a plurality of heat sinks.

9. The breath condensate sampler of claim 7, wherein the cooling apparatus and the cooling sleeve cool the condensate formation tube to a temperature between ten degrees Centigrade and negative ten degrees Centigrade.

10. A breath condensate sampler for use with a mechanical ventilator delivering respiratory support to a patient via a breathing circuit, the breath condensate sampler comprising:

an air flow valve configured to couple with the breathing circuit and to receive exhaled gases therefrom through an inlet, the air flow valve being movable between a first position that allows exhaled gases to flow from the inlet through the air flow valve and a second position that directs exhaled gases from the inlet into the breath condensate sampler;

a condensate formation tube connected to the air flow valve, the condensate formation tube separates a condensate portion of the exhaled gases from a gaseous portion of the exhaled gases and directs the gaseous portion out of the breath condensate sampler;

a condensate trap connected to the condensate formation tube, the condensate trap collects the condensate portion from the condensate formation tube; and

a condensate collection receptacle connected to the condensate trap, the condensate collection receptacle accumulates the condensate portion of the exhaled gases;

wherein the condensate formation tube further comprises a first condensate formation tube and a second condensate formation tube, the first and second condensate formation tubes being substantially vertical and connected to each other by the condensate trap, such that the exhaled gases are directed into the breath condensate sampler through the first condensate tube and out of the breath condensate sampler through the second condensate tube.

11. The breath condensate sampler of claim 10, further comprising surface area increasing tube components disposed within the first and second condensate formation tubes.

12. The breath condensate sampler of claim 11, wherein the tube components facilitate the gravitational accumulation of the condensate portion.

13. The breath condensate sampler of claim 12, wherein the tube components are downwardly directed annular flanges.

14. The breath condensate sampler of claim 10, wherein when the air flow valve is in the second position, the exhaled gases are directed through the first condensate formation tube, through the condensate trap, and through the second condensate formation tube before being directed out of the breath condensate sampler.

15. The breath condensate sampler of claim 14, further comprising a cooling apparatus coupled to the first condensate formation tube and the second condensate formation tube, the cooling apparatus cools the first and second condensate formation tube to a predetermined temperature.

16. The breath condensate sampler of claim 15 further comprising a volume indicator connected to the condensate receptacle, the volume indicator produces an indication of the volume of accumulated condensate portion.

17. A respiratory support system for providing respiratory support to a patient comprising:

an inspiratory limb connected to the patient that delivers fresh gas to the patient;

an expiratory limb connected to the patient that directs expired gas away from the patient;

an air flow valve connected in fluid communication with the expiratory limb, the air flow valve comprising an operational position that directs the expired gas into an inlet;

a first condensate formation tube connected to the inlet, the first condensate formation tube comprising a plurality of tube components that increase the surface area inside the first condensate formation tube, a condensate portion of the exhaled gases condenses on the plurality of tube components as the expired gas passes through the first condensate formation tube;

a condensate receptacle that accumulates the condensate portion;

a condensate trap connected to the first condensate formation tube and the condensate receptacle, the condensate trap collects the condensate portion from the first condensate formation tube and directs the condensate portion into the condensate receptacle; and

a second condensate formation tube connected to the condensate trap and comprising a plurality of tube components that increase the surface area inside the second condensate formation tube, the second condensate formation tube receiving the expired gases from the first condensate formation tube and directs the expired gas back to the expiratory limb, the condensate portion of the exhaled gas condenses on the plurality of tube components in the second condensate formation tube as the expired gas passes through the second condensate formation tube.

18. The respiratory support system of claim 17 wherein the plurality of tube components of the first and second condensate formation tubes are of a shape as to facilitate the gravitational accumulation of the condensate portion.

19. The respiratory support system of claim 18 further comprising a cooling apparatus coupled to the first second condensate formation tubes, and the cooling apparatus controls the temperature of the first and second condensate formation tubes.

20. The respiratory support system of claim 17 wherein the air flow valve further comprises a closed position that fluidly isolates the first and second condensate formation tubes, the condensate trap, and the condensate receptacle from the expiratory limb.

21. The respiratory support system of claim 20 wherein the condensate receptacle is removable from the condensate trap.