Medical device with therapeutic agents
First Claim
1. A medical device for at least partial implantation comprising:
- a main body having a length extending between a first end and a second end, the main body including a second tube at least partially positioned within a lumen of a first tube to form an annular space between an interior surface of the first tube and an exterior surface of the second tube, the second tube having a lumen extending from the first end to the second end;
a first section along the length of the main body proximate the first end of said main body and having a first therapeutic agent, said first therapeutic agent comprising one or more members selected from the group consisting of antiproliferatives, anticoagulants, antithrombotics, thrombolytics, and fibrinolytics; and
a second section along the length of the main body proximate the second end of said main body and having a second therapeutic agent, said second therapeutic agent comprising an antimicrobial, said first and second sections structured and aligned along said main body length such that said first therapeutic agent is at least substantially separated from said second therapeutic agent.
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Accused Products
Abstract
A medical device is adapted for at least partial implantation into a body and includes first and second sections along the length of the device. A first therapeutic agent is associated with the first section and a second therapeutic agent is associated with the second section. The first therapeutic agent can be one or more antiproliferative, such as paclitaxel, a paclitaxel derivative, or a paclitaxel pro-drug, anti-coagulant, antithrombotic, thrombolytic, fibrinolytic, or combination thereof. The second therapeutic agent can be one or more antimicrobials, such as one or more antibiotics. Each of the first and second therapeutic agents can either be posited on one or more surfaces of the respective section, or impregnated within the section. The device can include a separator to space the first and second sections. A method of making a medical device and a method of establishing access to a vessel within a body are also provided.
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Citations
20 Claims
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1. A medical device for at least partial implantation comprising:
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a main body having a length extending between a first end and a second end, the main body including a second tube at least partially positioned within a lumen of a first tube to form an annular space between an interior surface of the first tube and an exterior surface of the second tube, the second tube having a lumen extending from the first end to the second end; a first section along the length of the main body proximate the first end of said main body and having a first therapeutic agent, said first therapeutic agent comprising one or more members selected from the group consisting of antiproliferatives, anticoagulants, antithrombotics, thrombolytics, and fibrinolytics; and a second section along the length of the main body proximate the second end of said main body and having a second therapeutic agent, said second therapeutic agent comprising an antimicrobial, said first and second sections structured and aligned along said main body length such that said first therapeutic agent is at least substantially separated from said second therapeutic agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of establishing access to a vessel of the body, the method comprising
(a) implanting a distal portion of a medical device within a body vessel with a proximal portion of the medical device outside the body vessel, the medical device including: - (i) a main body having a length extending between a first end and a second end, the main body including a second tube at least partially positioned within a lumen of a first tube to form an annular space between an interior surface of the first tube and an exterior surface of the second tube, the second tube having a lumen extending from the first end to the second end;
(ii) a first section along the length of the main body proximate the first end of said main body and having a first therapeutic agent, said first therapeutic agent comprising one or more members selected from the group consisting of antiproliferatives, anticoagulants, antithrombotics, thrombolytics, and fibrinolytics; and
(iii) a second section along the length of the main body proximate the second end of said main body and having a second therapeutic agent, said second therapeutic agent comprising an antimicrobial, said first and second sections structured and aligned along said main body length such that said first therapeutic agent is at least substantially separated from said second therapeutic agent; and(b) forming an interface between the distal portion and the vessel to provide access to the vessel through the lumen of the second tube.
- (i) a main body having a length extending between a first end and a second end, the main body including a second tube at least partially positioned within a lumen of a first tube to form an annular space between an interior surface of the first tube and an exterior surface of the second tube, the second tube having a lumen extending from the first end to the second end;
Specification