Combination therapeutic compositions and method of use
First Claim
1. A pharmaceutical combination for treating diabetes mellitus, said combination comprising a therapeutically effective amount of metformin and a therapeutically effective amount of a pharmaceutically acceptable betaine selected from the group consisting of glycine betaine anhydrous, glycine betaine monohydrate and mixtures thereof.
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Abstract
The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound selected from one or more of betaines, lipidic betaines, betaine lipids and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, .alpha.-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound selected from one or more of betaines, lipidic betaines, betaine lipids is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound selected from one or more of betaines, lipidic betaines, betaine lipids. In the claims, betaine means pharmaceutically acceptable betaine, lipidic betaines, betaine lipids, pharmaceutically acceptable salts thereof and combinations thereof.
36 Citations
39 Claims
- 1. A pharmaceutical combination for treating diabetes mellitus, said combination comprising a therapeutically effective amount of metformin and a therapeutically effective amount of a pharmaceutically acceptable betaine selected from the group consisting of glycine betaine anhydrous, glycine betaine monohydrate and mixtures thereof.
- 22. A method for treating a human suffering from diabetes mellitus, said method comprising the step of administering orally at least daily a pharmaceutical combination comprising a therapeutically effective amount of metformin and a therapeutically effective amount of a pharmaceutically acceptable betaine selected from the group consisting of glycine betaine anhydrous, glycine betaine monohydrate and mixtures thereof.
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39. A method for modulating conditions associated with diabetes or diabetes-related disorders in a human, comprising administering orally to the human at least daily a pharmaceutical combination comprising a therapeutically effective amount of a metformin and a therapeutically effective amount of a pharmaceutically acceptable betaine selected from the group consisting of glycine betaine anhydrous, glycine betaine monohydrate and mixtures thereof.
Specification