Zwitterionic copolymers, method of making and use on medical devices

• US 7,781,551 B2
• Filed: 11/19/2007
• Issued: 08/24/2010
• Est. Priority Date: 11/21/2006
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories
• Original Assignee: Abbott Laboratories
• Inventors: Roorda, Wouter, Pacetti, Stephen
• Primary Examiner(s): PEZZUTO, HELEN LEE
• Application Number:
  US11/942,693
• Publication Number:
  US 20080147178A1
• Time in Patent Office: 1,009 Days
• Field of Search: 526/274, 526/277, 526/288, 526/310, 526/319, 526/320, 526/328.5, 526/329.6
• US Class Current: 526/288
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene

Abstract

Biocompatible copolymers are manufactured to include a zwitterionic monomer and an alkoxy acrylate monomer. The alkoxy acrylate monomer can be a 2-methoxyethyl methacrylate (MOEMA) or 2-ethoxyethyl methacrylate (EOEMA). Alternatively, the alkoxy acrylate can be 2-methoxyethyl acrylate (MOEA) or 2-ethoxyethyl acrylate (EOEA). The alkoxy acrylate monomers advantageously give the zwitterionic copolymers greater ductility, strength, and toughness while maintaining a desired amount of hydrophilicity. The improved toughness allows the zwitterionic copolymers to be processed without cross-linking, which improves the elongation properties of the zwitterionic copolymer, and reduces the risk of cracking during use.

Claims

1. A biocompatible polymer of the chemical formula:

2. A biocompatible polymer as in claim 1, in which R₅ is a methyl.

3. A biocompatible polymer as in claim 1, in which R₅ is an ethyl.

4. The biocompatible polymer of claim 1, wherein R₃ is selected from the group consisting of phosphorylcholine, phosphorylethanolamine, phosphatidylethanolamine, phosphatidylserine, sulfobetaine and combinations thereof.

5. The biocompatible polymer of claim 1, wherein the copolymer has a number average molecular weight of about 20 kD to about 800 kD.