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Method and apparatus for automated image analysis of biological specimens

  • US 7,783,098 B2
  • Filed: 08/29/2008
  • Issued: 08/24/2010
  • Est. Priority Date: 11/30/1995
  • Status: Expired due to Fees
First Claim
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1. A method of focusing, comprising:

  • acquiring, with an imaging device, a first electronic image of at least a portion of a slide presenting a medical sample;

    varying a focus of said slide by changing a distance between said slide and the imaging device to acquire a second electronic image;

    based on the acquiring and varying, fitting at least one characteristic of the first and second images to a Gaussian function;

    using said fitting to select an optimum focus by positioning the slide at a specified distance from the imaging device relative to a peak of said Gaussian function as an estimate of a coarse focus position;

    determining a fine focus position by finding a least squares fit to a second order polynomial; and

    positioning the imaging device at the fine focus position.

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