System and method for promoting intrinsic conduction through atrial timing modification and calculation of timing parameters

• US 7,783,350 B2
• Filed: 06/15/2006
• Issued: 08/24/2010
• Est. Priority Date: 06/15/2006
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Belk, Paul A., Sheldon, Todd J., Sweeney, Michael O.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US11/424,383
• Publication Number:
  US 20070293897A1
• Time in Patent Office: 1,531 Days
• Field of Search: 607/9, 607/17
• US Class Current: 607/9
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle in truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.

Claims

1. A method comprising:

operating an implantable medical device according to a ventricular pacing protocol (VPP) wherein ventricular pacing is precluded in a given cardiac cycle where a ventricular event occurred in a cardiac cycle immediately prior to the given cardiac cycle;

establishing an A-A interval;

initiating a first AV interval timer at the initiation of the given cardiac cycle;

sensing for ventricular events;

scheduling an early atrial pacing pulse at an accelerated atrial interval (AP(E)) prior to the termination of the A-A interval if no ventricular event is sensed within the duration of the AV interval timer, wherein the interval from an immediately preceding atrial event (A) to the AP(E) (A-AP(E)) is ≧

the AV interval timer, is ≦

a lower rate interval (LRI), and the AP(E) is selected to lead to a likely ventricular event (Target VS) at a predetermined time; and

canceling the early atrial pacing pulse and reverting to the A-A interval if a ventricular event is sensed prior to the early atrial pacing pulse.

2. The method of claim 1, wherein the PAV is ≦

LRI−

(AAP(E))+PAV_c, wherein PAV_c is predetermined duration for a ventricular backup pace in the VPP.

3. The method of claim 2 wherein PAV_c is 80 ms.

4. The method of claim 1, wherein establishing the A-A interval includes measuring intervals between sensed intrinsic atrial events.

5. The method of claim 1, wherein establishing the A-A interval includes identifying an atrial escape interval.

6. The method of claim 1, wherein the first AV interval timer has a duration determined by patient specific intrinisic AV conduction time.

7. The method of claim 6, wherein the first AV interval timer is an average of AV conduction times over a plurality of cardiac cycles.

8. The method of claim 6, wherein the patient specific AV conduction times are correlated to cardiac rate.

9. A method comprising:

operating an implantable medical device according to a ventricular pacing protocol (VPP) wherein ventricular pacing is precluded in a given cardiac cycle where a ventricular event occurred in a cardiac cycle immediately prior to the given cardiac cycle;

establishing an A-A interval;

initiating a first AV interval timer at the initiation of the given cardiac cycle;

sensing for ventricular events;

scheduling an early atrial pacing pulse at an accelerated atrial interval (AP(E)) prior to the termination of the A-A interval if no ventricular event is sensed within the duration of the AV interval timer, wherein the interval from an immediately preceding atrial event (A) to the AP(E) (A-AP(E)) is ≧

the AV interval timer, is ≦

a lower rate interval (LRI), and the AP(E) is selected to lead to a likely ventricular event (Target VS) at a predetermined time;

initiating a paced atrio-ventricular (PAV) interval upon delivery of the early atrial pace; and

delivering a ventricular pace at the expiration of the PAV interval timer unless inhibited by a sensed ventricular event, wherein the PAV≧

AP(E)Target VS.

10. The method of claim 9, wherein the PAV is less that 2*LRI.

11. A method comprising:

operating an implantable medical device according to a ventricular pacing protocol (VPP) wherein ventricular pacing is precluded in a given cardiac cycle where a ventricular event occurred in a cardiac cycle immediately prior to the given cardiac cycle;

establishing an A-A interval;

initiating a first AV interval timer at the initiation of the given cardiac cycle;

sensing for ventricular events;

scheduling an early atrial pacing pulse at an accelerated atrial interval (AP(E)) prior to the termination of the A-A interval if no ventricular event is sensed within the duration of the AV interval timer, wherein the interval from an immediately preceding atrial event (A) to the AP(E) (A-AP(E)) is ≧

the AV interval timer, is ≦

a lower rate interval (LRI), and the AP(E) is selected to lead to a likely ventricular event (Target VS) at a predetermined time; and

comparing the A-AP(E) interval to data recorded in the memory of the IMD and only implement the A-AP(E) interval if the data indicates successful intrinsic conduction has previously occurred at the atrial rate resulting from the A-AP(E) interval.

12. An implantable medical device comprising:

means for operating an implantable medical device (IMD) according to a ventricular pacing protocol (VPP) wherein ventricular pacing is precluded in a given cardiac cycle wherein a ventricular event occurred in a cardiac cycle immediately subsequent to the given cardiac cycle;

means for establishing an A-A interval;

means for initiating a first AV interval timer at the initiation of the given cardiac cycle;

means for sensing for ventricular events;

means for scheduling an early atrial pacing (AP(E) pulse prior to the termination of the A-A interval if no ventricular event is sensed within the duration of the AV interval timer, wherein the interval from an immediately preceding atrial event (A) to the AP(E) (A-AP(E)) is ≧

the AV interval timer, is ≦

a lower rate interval (LRI), and the AP(E) is selected to lead to a likely ventricular event (Target VS) at a predetermined time; and

means for canceling the atrial pacing pulse and reverting to the A-A interval if a ventricular event is sensed prior to the atrial pacing pulse.

13. An implantable medical device comprising:

means for operating an implantable medical device (IMD) according to a ventricular pacing protocol (VPP) wherein ventricular pacing is precluded in a given cardiac cycle wherein a ventricular event occurred in a cardiac cycle immediately subsequent to the given cardiac cycle;

means for establishing an A-A interval;

means for initiating a first AV interval timer at the initiation of the given cardiac cycle;

means for sensing for ventricular events;

means for scheduling an early atrial pacing (AP(E) pulse prior to the termination of the A-A interval if no ventricular event is sensed within the duration of the AV interval timer, wherein the interval from an immediately preceding atrial event (A) to the AP(E) (A-AP(E)) is ≧

the AV interval timer, is ≦

a lower rate interval (LRI), and the AP(E) is selected to lead to a likely ventricular event (Target VS) at a predetermined time; and

means for initiating a paced atrio-ventricular (PAV) interval timer upon delivery of the early atrial pace;

means for delivering a ventricular pace at the expiration of the PAV interval timer unless inhibited by a sensed ventricular event, wherein the PAV≧

AP(E)Target VS.

14. The IMD of claim 13, wherein the PAV is less that 2*LRI.

15. The IMD of claim 13 the PAV is ≦

LRI−

(AAP(E))+PAV_c, wherein PAV_c is predetermined duration for a ventricular backup pace in the VPP.

16. The IMD of claim 15, wherein PAV_c is 80 ms.