Use of synovium and omentum for tissue engineering

• US 7,785,582 B2
• Filed: 08/23/2005
• Issued: 08/31/2010
• Est. Priority Date: 09/07/2004
• Status: Active Grant

• Current Assignee: Lanny L. Johnson
• Original Assignee: Lanny L. Johnson
• Inventors: Johnson, Lanny L.
• Primary Examiner(s): Weber; Jon P
• Assistant Examiner(s): GOUGH, TIFFANY MAUREEN
• Application Number:
  US11/210,077
• Publication Number:
  US 20060051327A1
• Time in Patent Office: 1,834 Days
• Field of Search: 424/93.7
• US Class Current: 424/93.7
• CPC Class Codes: A61K 35/32 Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane

Abstract

A method for treating a patient to repair or regenerate damaged tissues or organs in which synovium from a joint or omentum from the abdomen are harvested to provide explants, optionally separating cells from the synovium or omentum explants for culture or tissue specification, and introducting the explants or separated cells from the synovium or omentum into damaged tissues or organs to repair the damaged tissues or organs.

Claims

1. A method for treating a patient to repair damaged articular cartilage, which comprises:

(a) harvesting of synovial villi from a synovial membrane of a joint of the patient to provide an explant; and

(b) introducing the explant into the damaged cartilage, so as to repair the damaged cartilage, wherein the introduced explant comprises synovial villi and all of its harvested components.

2. The method of claim 1, wherein the introduced explant comprises synovial cells, fibroblasts, lymphocytes and angioblasts.

3. The method of claim 1, wherein the introduced explant comprises adipose tissue.

4. The method of claim 1, further comprising the step of culturing the explant in vitro prior to the step of introducing the explant into the damaged tissue.

5. The method of claim 1, further comprising the step of morcellizing the explant prior to the step of introducing the explant into the damaged tissue.

6. A method for treating a patient to repair damaged articular cartilage, comprising:

a) harvesting a plurality of synovial villi from a joint of the patient;

b) mincing or morcellizing the collected synovial villi to provide an explant; and

c) introducing the explant into the damaged articular cartilage, so as to repair the damaged cartilage.

7. The method of claim 6, wherein the introduced explant comprises synovial cells, fibroblasts, lymphocytes and angioblasts.

8. The method of claim 6, wherein the introduced explant comprises adipose tissue.

9. The method of claim 6, further comprising the step of culturing the explant in vitro prior to the step of introducing the explant into the damaged tissue.