Albumin fusion proteins
First Claim
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1. A method of treating Hepatitis, Cancer, or HIV in a patient, comprising:
- administering a fusion protein comprising a human serum albumin (HSA) protein and a human interferon alpha polypeptide, wherein the HSA protein comprises the amino acid sequence of SEQ ID NO;
18 and increases the serum plasma half-life of the human interferon alpha polypeptide compared with a human interferon alpha polypeptide that is not fused to the the HSA protein.
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Abstract
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encodings the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the intention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
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19 Claims
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1. A method of treating Hepatitis, Cancer, or HIV in a patient, comprising:
administering a fusion protein comprising a human serum albumin (HSA) protein and a human interferon alpha polypeptide, wherein the HSA protein comprises the amino acid sequence of SEQ ID NO;
18 and increases the serum plasma half-life of the human interferon alpha polypeptide compared with a human interferon alpha polypeptide that is not fused to the the HSA protein.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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