Compositions and methods for treating allergies, auto-immune diseases, and improving skin condition by ganoderma lucidum (reishi) polysaccharides

• US 7,785,600 B2
• Filed: 08/29/2008
• Issued: 08/31/2010
• Est. Priority Date: 08/30/2007
• Status: Active Grant

• Current Assignee: Academia Sinica (Government of The Republic of China), Wyntek Corporation
• Original Assignee: Academia Sinica (Government of The Republic of China), Wyntek Corporation
• Inventors: Wong, Chi-Huey, Fan, Eugene, Tu, Tseng-Rong, Su, Sung-Hsieh, Li, Chia-Feng
• Primary Examiner(s): Tate; Christopher R
• Assistant Examiner(s): WINSTON, RANDALL O
• Application Number:
  US12/201,879
• Publication Number:
  US 20090060939A1
• Time in Patent Office: 732 Days
• Field of Search: None
• US Class Current: 424/195.15
• CPC Class Codes: A61K 36/074 Ganoderma
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection

Abstract

A method for treating an allergy by providing a pharmaceutical composition containing at least Ganoderma lucidum extract and administering a therapeutically effective amount of the composition to a patient in need thereof. Also disclosed is a method for treating an allergy by first purifying Ganoderma lucidum extract into at least one fraction, then providing a pharmaceutical composition comprising at least one of the Ganoderma lucidum fractions, and administering a therapeutically effective amount of the composition to a patient in need thereof. A method for alleviating symptoms of an allergy is disclosed. The symptoms of the allergy are alleviated by providing a pharmaceutical composition containing at least Ganoderma lucidum extract and administering an amount of the composition effective to decrease at least one of an IgE and IgG2a level, whereby the symptoms of the allergy are ameliorated.

Claims

1. A method for treating an allergy, the method comprising:

providing a pharmaceutical composition comprising a sodium hydroxide extract solution of Ganoderma lucidum; and

administering a therapeutically effective amount of the composition to a patient in need thereof.

2. The method of claim 1 wherein said composition is administered intravenously, intradermally, subcutaneously, orally, transdermally, transmucosally, or rectally.

3. The method of claim 1 wherein said composition is formulated as a cream, gel, salve, ointment, solution, tablet, capsule, spray, or patch.

4. The method of claim 1 wherein the administration of said Ganoderma lucidum extract decreases IgE levels in the patient.

6. The method of claim 1, wherein the composition is administered in an amount sufficient for inducing an increase in at least one of IL-10 and IL-1Ra expression.

5. A method for alleviating symptoms of an allergy, the method comprising:

providing a pharmaceutical composition comprising a sodium hydroxide extract solution of Ganoderma lucidum; and

administering an amount of the composition effective to decrease at least one of an IgE and IgG2a level, whereby the symptoms of the allergy are ameliorated.