Chimeric immunomodulatory compounds and methods of using the same—III
First Claim
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1. A method of modulating an immune response in an individual comprising administering to an individual a branched chimeric immunomodulatory compound (CIC) in an amount sufficient to modulate an immune response in said individual, wherein:
- the CIC comprises at least three nucleic acid moieties and one or more non-nucleic acid, spacer moieties;
each nucleic acid moiety is covalently joined to at least one non-nucleic acid spacer moiety;
at least one nucleic acid moiety comprises the sequence 5′
-CG-3′
; and
said CIC has immunomodulatory activity.
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Abstract
The invention provides immunomodulatory compounds and methods for immunomodulation of individuals using the immunomodulatory compounds.
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Citations
7 Claims
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1. A method of modulating an immune response in an individual comprising administering to an individual a branched chimeric immunomodulatory compound (CIC) in an amount sufficient to modulate an immune response in said individual, wherein:
- the CIC comprises at least three nucleic acid moieties and one or more non-nucleic acid, spacer moieties;
each nucleic acid moiety is covalently joined to at least one non-nucleic acid spacer moiety;
at least one nucleic acid moiety comprises the sequence 5′
-CG-3′
; and
said CIC has immunomodulatory activity. - View Dependent Claims (2, 5, 6, 7)
- the CIC comprises at least three nucleic acid moieties and one or more non-nucleic acid, spacer moieties;
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3. A method of modulating an immune response of a population of cells, comprising contacting the population with a composition comprising a branched chimeric immunomodulatory compound (CIC) wherein:
- the CIC comprises at least three nucleic acid moieties and one or more non-nucleic acid spacer moieties;
each nucleic acid moiety is covalently joined to at least one non-nucleic acid spacer moiety;
at least one nucleic acid moiety comprises the sequence 5′
-CG-3′
; and
said CIC has immunomodulatory activity. - View Dependent Claims (4)
- the CIC comprises at least three nucleic acid moieties and one or more non-nucleic acid spacer moieties;
Specification