Vaginal treatment composition containing xylitol
First Claim
1. A vaginal treatment composition comprising:
- at least one low acyl gellan gum capable of forming a gel in the presence of monovalent or polyvalent cations;
xylitol in an amount of from about 0.01 wt/vol % to about 20 wt/vol %; and
At least one phenolic acid selected from the group consisting of p-hydrobenzoic acid, protocatechuic acid, vanillic acid, chlorogenic acid, caffeic acid, ferulic acid, gallic acid, sinapic acid, syringic acid, coumaric acid, cinnamic acid, gentisic acid, salicylic acid, veratric acid, anisic acid, crotonic acid, hydroxy benzoic acid, hydroxy phenyl acetic acids, and combinations thereof ;
wherein the vaginal treatment composition has an osmolarity of from about 270 to about 310 milliosmoles per liter and a pH of from about 2.5 to about 5.0, andwherein the composition lacks monovalent and divalent salts in an amount sufficient for gelation, such that a gel is formed only after the composition is delivered to the vaginal of a female.
2 Assignments
0 Petitions
Accused Products
Abstract
A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
-
Citations
15 Claims
-
1. A vaginal treatment composition comprising:
-
at least one low acyl gellan gum capable of forming a gel in the presence of monovalent or polyvalent cations; xylitol in an amount of from about 0.01 wt/vol % to about 20 wt/vol %; and At least one phenolic acid selected from the group consisting of p-hydrobenzoic acid, protocatechuic acid, vanillic acid, chlorogenic acid, caffeic acid, ferulic acid, gallic acid, sinapic acid, syringic acid, coumaric acid, cinnamic acid, gentisic acid, salicylic acid, veratric acid, anisic acid, crotonic acid, hydroxy benzoic acid, hydroxy phenyl acetic acids, and combinations thereof ; wherein the vaginal treatment composition has an osmolarity of from about 270 to about 310 milliosmoles per liter and a pH of from about 2.5 to about 5.0, and wherein the composition lacks monovalent and divalent salts in an amount sufficient for gelation, such that a gel is formed only after the composition is delivered to the vaginal of a female. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
-
Specification