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Antisense agents combining strongly bound base-modified oligonucleotide and artificial nuclease

  • US 7,786,292 B2
  • Filed: 04/30/2007
  • Issued: 08/31/2010
  • Est. Priority Date: 05/03/2006
  • Status: Expired due to Fees
First Claim
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1. A compound comprising an oligonucleotide having from 5 to 150 nucleobases and a chelating moiety attached to the oligonucleotide, wherein at least 10% of said nucleobases are a modified nucleobase selected from the group consisting of:

  • 5-mercaptocytosine, 5-mercaptouracil, 8-mercaptoguanine, 8-mercaptoadenine, 5-hydroxycytosine, 5-hydroxyuracil, 8-hydroxyadenine and 8-hydroxyguanine.

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