Depth of field extension for optical tomography
First Claim
1. An optical projection tomography system for imaging an object of interest, the optical projection tomography system comprising:
- (a) a light source;
(b) an object-containing tube, a portion of which is located within the region illuminated by the light source, wherein the object of interest has at least one feature of interest located within the object-containing tube;
(c) at least one detector, wherein the at least one detector is located to receive emerging radiation from the object of interest; and
wherein the object of interest is stained to impart an absorption coefficient of at least on wavelength; and
(d) at least one lens located in the optical path between the object region and the at least one detector, wherein the at least one lens includes at least one optical field extension element such that light rays from multiple object planes in the object-containing tube simultaneously focus on the at least one detector.
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Accused Products
Abstract
An optical projection tomography system is illuminated with a light source. An object-containing tube, a portion of which is located within the region illuminated by the light source, contains an object of interest that has a feature of interest. A detector is located to receive emerging radiation from the object of interest. A lens, including optical field extension elements, is located in the optical path between the object region and the detector, such that light rays from multiple object planes in the object-containing tube simultaneously focus on the detector. The object-containing tube moves relatively to the detector and the lens operate to provide multiple views of the object region for producing an image of the feature of interest at each view.
152 Citations
47 Claims
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1. An optical projection tomography system for imaging an object of interest, the optical projection tomography system comprising:
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(a) a light source; (b) an object-containing tube, a portion of which is located within the region illuminated by the light source, wherein the object of interest has at least one feature of interest located within the object-containing tube; (c) at least one detector, wherein the at least one detector is located to receive emerging radiation from the object of interest; and
wherein the object of interest is stained to impart an absorption coefficient of at least on wavelength; and(d) at least one lens located in the optical path between the object region and the at least one detector, wherein the at least one lens includes at least one optical field extension element such that light rays from multiple object planes in the object-containing tube simultaneously focus on the at least one detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. An optical projection tomography method for imaging an object of interest, the optical projection tomography method comprising:
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(a) staining an object of interest to impart an absorption coefficient of at least one wavelength when illuminated; (b) illuminating the object of interest; (c) locating at least one lens in the optical path between the object of interest and at least one detector, wherein the at least one lens includes at least one optical field extension element such that light rays from multiple object planes in the object of interest simultaneously focus on the at least one detector. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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Specification