Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
First Claim
1. A detection system for detecting target material comprising:
- a photonic structure having a reflectance-band and associated side bands;
an illumination source for illuminating at a wavelength in at least one of an edge of the reflectance-band and the side bands of the photonic structure and for generating a return beam;
a detector system having an intensity-sensitive channel configured to detect an in-line signal from the return beam and a phase-sensitive channel configured to detect a differential phase contrast signal from the return beam; and
a processing system for receiving and adding in quadrature the in-line signal and the differential phase contrast signal to generate a joint signal, and for determining one of the presence or the absence of the target material on the photonic structure using the joint signal.
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Abstract
A detection system for detecting target material is provided. The system comprises a photonic structure having a reflectance-band and associated side bands; an illumination source for illuminating at a wavelength in at least one of an edge of the reflectance-band and the side bands of the photonic structure and for generating a return beam; a detector system having an intensity-sensitive channel configured to detect an in-line signal from the return beam and a phase-sensitive channel configured to detect a differential phase contrast signal from the return beam; and a processing system for receiving and adding in quadrature the in-line signal and the differential phase contrast signal to generate a joint signal, and for determining one of the presence or the absence of the target material on the photonic structure using the joint signal.
242 Citations
10 Claims
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1. A detection system for detecting target material comprising:
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a photonic structure having a reflectance-band and associated side bands; an illumination source for illuminating at a wavelength in at least one of an edge of the reflectance-band and the side bands of the photonic structure and for generating a return beam; a detector system having an intensity-sensitive channel configured to detect an in-line signal from the return beam and a phase-sensitive channel configured to detect a differential phase contrast signal from the return beam; and a processing system for receiving and adding in quadrature the in-line signal and the differential phase contrast signal to generate a joint signal, and for determining one of the presence or the absence of the target material on the photonic structure using the joint signal. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for detecting the presence of an antigen on a photonic structure, the method comprising:
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exposing the photonic structure to a sample that may contain the antigen, the photonic structure having a reflectance-band and side bands; illuminating at a wavelength in at least one of an edge of the reflectance-band and the side bands of the photonic structure with an illumination source to create a return beam; detecting the return beam with a detector system having an intensity-sensitive detection function and a phase-sensitive detection function; detecting an in-line quadrature signal from the return beam using the intensity-sensitive detection function of the detector system; detecting a differential phase contrast quadrature signal from the return beam using the phase-sensitive detection function of the detector system; receiving the in-line quadrature signal and the differential phase contrast quadrature signal; combining the in-line quadrature signal and the differential phase contrast quadrature signal to generate a joint signal, and determining one of the presence or the absence of the target material on the photonic structure using the joint signal. - View Dependent Claims (9, 10)
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Specification