Methods, device and system for in vivo detection

• US 7,787,928 B2
• Filed: 06/28/2004
• Issued: 08/31/2010
• Est. Priority Date: 11/29/2002
• Status: Expired due to Fees

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Given Imaging Limited (Medtronic Plc)
• Inventors: Schreiber, Reuven, Iddan, Gavriel J., Gilad, Zvika, Frisch, Mordechai
• Primary Examiner(s): Casler; Brian
• Assistant Examiner(s): Roy; Baisakhi
• Application Number:
  US10/876,741
• Publication Number:
  US 20050043617A1
• Time in Patent Office: 2,255 Days
• Field of Search: 600/109, 600/160, 600309-310, 600/347, 600/407, 600/424, 600/427, 600/437, 600/476, 600/478, 600/317, 600/118, 600/473, 600/585, 128/903, 378/44, 378 62- 63, 378/119, 348/65, 348/77
• US Class Current: 600/407
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: Y10S 128/903 Radio telemetry

Abstract

A system and method for in vivo diagnosis are provided. A composition including for example a radioactive marking agent and a pharmaceutically acceptable carrier is administered to a patient and an autonomous in vivo device, which may include for example an illumination source an image sensor and a radiation and/or light detector, is used to for example facilitate the difference between. normal and pathological cells in a body lumen.

Claims

1. An autonomous in vivo device comprising:

an optical dome;

an illumination source for illuminating a body lumen through the optical dome;

a radiation detector unit capable of generating light pulses within said device;

a image sensor for imaging the body lumen as a result of illumination reflected from said body lumen and received through the optical dome, and comprising at least first and second non-overlapping portions, each portion having one or more pixels; and

a transmitter,

wherein said radiation detector unit is placed directly on said first portion of pixels of the image sensor such that said first portion does not receive illumination reflected from said body lumen, and wherein said second portion of pixels of the image sensor is configured for capturing images of a body lumen.

2. The device according to claim 1 wherein said radiation detector unit comprises a scintillator.

3. The device according to claim 2 wherein said scintillator is selected from the group consisting of solid, gas, liquid.

4. The device according to claim 2 wherein said scintillator is selected from the group consisting of NaI(T1), CsI(T1), CsI(Na), Ce-141.

5. The device according to claim 1 wherein said radiation detector unit comprises a photomultiplier.

6. The device according to claim 1 wherein said radiation detector unit is configured to detect ionizing radiation, said ionizing radiation selected from the group consisting of:

gamma-rays, x-rays, alpha particles and beta particles.

7. The device according to claim 1, wherein said device is autonomous.

8. The device according to claim 1, wherein said image sensor is selected from the group consisting of a CMOS and a CCD.

9. The device according to claim 1, wherein said transmitter is a radio frequency transmitter.

10. The device according to claim 1, wherein said radiation detector unit is placed within an optical dome.

11. The device according to claim 1, comprising a processor.

12. The device according to claim 11, wherein said processor is a radiation data processor.

13. The device according to claim 1, comprising a power source.

14. The device according to claim 13, wherein said power source is an external power source.

15. An autonomous in vivo device comprising:

an optical dome;

a radiation detector unit capable of generating light pulses within said device;

an illumination source for illuminating a body lumen through the optical dome;

an image sensor for imaging the body lumen as a result of illumination reflected from said body lumen and received through the optical dome, and comprising at least first and second non-overlapping portions, each portion having one or more pixels;

an optical system for focusing light from said illumination source reflected from said body lumen through said optical dome onto said first portion of the image sensor for obtaining images of the body lumen;

a light diverter for diverting the direction of the light pulses from said radiation detector towards said second portion of the image sensor; and

a transmitter.

16. The device according to claim 15 wherein said radiation detector unit comprises a scintillator.

17. The device according to claim 16 wherein said scintillator is selected from the group consisting of:

solid, gas, liquid.

18. The device according to claim 15 wherein said scintillator is selected from the group consisting of:

NaI(T1), CsI(T1), CsI(Na), Ce-141.

19. The device according to claim 15 wherein said radiation detector unit comprises a photomultiplier.

20. The device according to claim 15 wherein said radiation detector unit is configured to detect ionizing radiation, said ionizing radiation selected from the group consisting of gamma-rays, x-rays, alpha particles and beta particles.

21. The device according to claim 15, wherein said light diverter is selected from the group consisting of optical fibers, light pipes, prisms, and mirrors.