Systems, methods, and devices relating to a cellularized nephron unit
First Claim
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1. A bioartificial device comprising:
- a microfabricated blood flow layer having a first microfluidic channel formed therein for carrying blood, the first microfluidic channel including a loop, and wherein portions of the loop in the first microfluidic channel are separated by a porous medium;
a microfabricated filtrate layer having a second microfluidic channel formed therein for carrying a filtrate flow, the second microfluidic channel including a loop having an ascending limb seeded with salt-pumping cells and a descending limb seeding with water permeable cells; and
a permeable membrane positioned between the blood flow layer and the filtrate layer coupling the blood flow layer to the filtrate layer.
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Abstract
The present invention relates to bioartificial devices and systems that mimic kidney or nephron function and methods of making them.
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Citations
22 Claims
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1. A bioartificial device comprising:
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a microfabricated blood flow layer having a first microfluidic channel formed therein for carrying blood, the first microfluidic channel including a loop, and wherein portions of the loop in the first microfluidic channel are separated by a porous medium; a microfabricated filtrate layer having a second microfluidic channel formed therein for carrying a filtrate flow, the second microfluidic channel including a loop having an ascending limb seeded with salt-pumping cells and a descending limb seeding with water permeable cells; and a permeable membrane positioned between the blood flow layer and the filtrate layer coupling the blood flow layer to the filtrate layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification