Compositions for delivery of therapeutics and other materials, and methods of making and using the same
First Claim
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1. A biocompatible composition comprising:
- a carrier with a first metal binding domain (MBD),a metal ion chelated to the first MBD,an active agent with a second MBD chelated to the metal ion, andone or more protective groups covalently bonded to the carrierwherein the first MBD, the metal ion, and the second MBD form a metal ion bridge and wherein after administration of the composition to a patient, the active agent is released from the composition.
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Abstract
In part, the present invention is directed to biocompatible compositions comprising a carrier with a first metal binding domain, a metal ion, an active agent with second metal binding domain and optionally a protective chain covalently attached to the polymeric carrier.
151 Citations
24 Claims
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1. A biocompatible composition comprising:
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a carrier with a first metal binding domain (MBD), a metal ion chelated to the first MBD, an active agent with a second MBD chelated to the metal ion, and one or more protective groups covalently bonded to the carrier wherein the first MBD, the metal ion, and the second MBD form a metal ion bridge and wherein after administration of the composition to a patient, the active agent is released from the composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification