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Method for creating polynucleotide and polypeptide sequences

  • US 7,790,381 B2
  • Filed: 12/07/2006
  • Issued: 09/07/2010
  • Est. Priority Date: 12/08/1997
  • Status: Expired due to Fees
First Claim
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1. A method for evolving a polynucleotide toward acquisition of a desired property, comprising(a) incubating a population of parental polynucleotide variants comprising allelic or species variants of a gene, or mutants created by error-prone PCR, under conditions to generate annealed polynucleotides comprising heteroduplexes;

  • (b) exposing the heteroduplexes to enzymes of a DNA repair system to convert the heteroduplexes to parental polynucleotide variants or recombined polynucleotide variants;

    (c) screening or selecting the recombined polynucleotide variants for the desired property.

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