Compositions and methods for treatment of body weight conditions

• US 7,790,670 B2
• Filed: 10/20/2004
• Issued: 09/07/2010
• Est. Priority Date: 03/01/2002
• Status: Active Grant

• Current Assignee: Glanbia Nutritionals Ireland Ltd (Glanbia Company-Operative Society Limited)
• Original Assignee: Glanbia Nutritionals Ireland Ltd (Glanbia Company-Operative Society Limited)
• Inventors: Paulsen, Starla Joyce, Bastian, Eric Douglas, Ward, Loren Spencer
• Primary Examiner(s): Levy; Neil
• Application Number:
  US10/969,468
• Publication Number:
  US 20050106218A1
• Time in Patent Office: 2,148 Days
• Field of Search: 424/755, 514/23, 514/2
• US Class Current: 514/5.7
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/18 Peptides; Protein hydrolysates
• CPC Class Codes: A23L 33/185 Vegetable proteins
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23L 33/30 Dietetic or nutritional methods, e.g. for losing weight A23L33/10 takes precedence
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/332 Promoters of weight control and weight loss
• CPC Class Codes: A23V 2250/1644 Milk minerals
• CPC Class Codes: A23V 2250/5036 Carrageenan
• CPC Class Codes: A23V 2250/50364 Kappa-carrageenan
• CPC Class Codes: A23V 2250/5114 Dextrins, maltodextrins
• CPC Class Codes: A23V 2250/54246 Casein
• CPC Class Codes: A23V 2250/606 Fructose
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/14 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 35/20 : Milk; Whey; Colostrum
• CPC Class Codes: A61K 36/48 : Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 38/005 : Enzyme inhibitors protease inhibitors A61K38/55
• CPC Class Codes: A61K 38/556 : Angiotensin converting enzyme inhibitors
• CPC Class Codes: A61K 45/06 : Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/26 : Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 47/36 : Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/42 : Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61K 47/46 : Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• CPC Class Codes: A61K 9/0095 : Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006

Abstract

A nutritional supplement composition having therapeutically effective amounts of milk minerals including calcium, a protein source including κ-casein fragment 106-169, and enzyme-inhibiting peptides is provided for the treatment of body weight conditions. The nutritional supplement composition is administered in amounts effective for limiting weight gain and/or enhancing weight loss, as well as promoting overall good health, in the treatment of body weight conditions, including overweight and obesity.

Claims

1. A method for decreasing fat mass and body weight in a human subject consuming a hypocaloric diet, the method comprising administering to the subject a composition comprising from about 2 to about 20 grams per serving of angiotensin converting enzyme-inhibiting peptides, from about 3 to about 10 grams per serving of κ

-casein fragment 106-109, and from about 0.5 to about 6 grams per serving of calcium, the angiotensin converting enzyme-inhibiting peptides, κ

-casein fragment 106-109, and calcium being derived from milk.

2. The method of claim 1 wherein the composition comprises from about 4 to about 20 grams per serving of angiotensin converting enzyme-inhibiting peptides, from about 4 to about 10 grams per serving of κ

-casein fragment 106-109, and from about 1 to about 6 grams per serving of calcium, the angiotensin-converting enzyme-inhibiting peptides, κ

-casein fragment 106-109, and calcium being derived from milk.

3. The method of claim 1 wherein the hypocaloric diet is a mildly hypocaloric diet.

4. The method of claim 1 wherein the hypocaloric diet reduces energy intake by at least 20 calories per day.