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Implantable pump for protein delivery for obesity control by drug infusion into the brain

  • US 7,790,671 B2
  • Filed: 10/07/2005
  • Issued: 09/07/2010
  • Est. Priority Date: 10/07/2005
  • Status: Expired due to Fees
First Claim
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1. A method of suppressing appetite comprising:

  • implanting a drug infusion pump into a site in a subject; and

    delivering a stable suspension of an effective dosage of an appetite suppressing agent to a site in a central nervous system of the subject, the appetite suppressing agent comprising a polypeptide having the general formula;


    (Mp-Lk-V2—

    Hg—

    CH2—

    CH3)(t) wherein Mp is an alpha melanocyte-stimulating hormone (α

    -MSH) peptide, LK is a polypeptide or chemical linkage, V2 is a portion of a C-terminus of an immunoglobulin variable region, Hg is at least a portion of an immunoglobulin variable hinge region, CH2 is an immunoglobulin heavy chain CH2 constant region, CH3 is an immunoglobulin heavy chain CH3 constant region, and t is an integer of 1 to 10, wherein the appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.

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