Device for implementation and monitoring of thermal ablation and associated method

• US 7,792,566 B2
• Filed: 08/13/2007
• Issued: 09/07/2010
• Est. Priority Date: 08/29/2006
• Status: Expired due to Fees

• Current Assignee: Siemens Healthcare GMBH (Siemens AG)
• Original Assignee: Siemens AG
• Inventors: Roland, Joerg, Steinmeyer, Florian
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): BOR, HELENE CATHERINE
• Application Number:
  US11/837,823
• Publication Number:
  US 20080058634A1
• Time in Patent Office: 1,121 Days
• Field of Search: 600/421, 600/411, 600/427, 600/407, 606/27
• US Class Current: 600/411
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 5/015 By temperature mapping of body part
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A device for implementation and monitoring of thermal ablation has a device for generation of high intensity ultrasound and a magnetic resonance system for generation of examination images composed of voxels that contain temperature information. The geometry of the voxels is adapted to the shape of the ultrasound focus.

Claims

1. A method for implementing and monitoring a thermal ablation procedure comprising:

conducting a thermal ablation procedure by directing high intensity focused ultrasound at an ultrasound focus having an elongated focus shape encompassing tissue to be ablated in a subject;

for an image composed of voxels representing a region of the subject encompassing said ultrasound focus, setting, in a computer, a cuboid shape of each of said voxels, as adapted voxels, dependent on said focus shape; and

in said computer, generating said image of said region of the subject by composing said image of said adapted voxels, and including a representation of said ultrasound focus, with said cuboid shape, in said image composed of said adapted voxels.

2. A method as claimed in claim 1 comprising directing said high intensity focused ultrasound at said subject with an ellipsoid focus shape, and composing said image of non-cubic parallelpiped adapted voxels having a longer side and a shorter side, with the longer side of each voxel being substantially parallel to the primary axis of said ellipsoid ultrasound focus.

3. A method as claimed in claim 2 comprising composing said image of adapted voxels having said longer side in a ratio to said primary axis of approximately 1:

3 or less.

4. A method as claimed in claim 2 comprising generating said image as a slice image and forming said ultrasound focus in said slice image with a plurality of said adapted voxels in a range between six adapted voxels and nine adapted voxels.

5. A method as claimed in claim 2 comprising composing said image of adapted voxels having a ratio between said longer side and said shorter side is in a range between 2:

1 and 5;

1.

6. A method as claimed in claim 5 comprising composing said image of adapted voxels having a ratio between said longer side and said shorter side of approximately 3:

1.

7. A method as claimed in claim 2 comprising composing said image of adapted voxels having a ratio between said longer side and said shorter side corresponding to a ratio between the primary axis and the secondary axis of said ellipsoid ultrasound focus.

8. A method as claimed in claim 1 comprising setting the cuboid shape of each of said adapted voxels to be the same for all of said adapted voxels.

9. A method for magnetic resonance monitoring of an ablation procedure conducted at a subject using high intensity focused ultrasound directed at the subject in an ultrasound focus having an elongated focus shape, comprising the steps of:

acquiring magnetic resonance data from the subject during said ablation procedure, said magnetic resonance data including temperature information of tissue affected by said ablation procedure;

for a magnetic resonance image from said magnetic resonance data composed of voxels, setting, in a computer, a cuboid shape of each of said voxels, as adapted voxels, dependent on said focus shape and

in said computer, generating said magnetic resonance image of said region of the subject by composing said image of said adapted voxels, and including a representation of said ultrasound focus, with said cuboid shape, in said image composed of said adapted voxels.

10. A method as claimed in claim 9 comprising directing said high intensity focused ultrasound at said subject with an ellipsoid focus shape, and composing said magnetic resonance image of non-cubic parallelpiped adapted voxels having a longer side and a shorter side, with the longer side of each voxel being substantially parallel to the primary axis of said ellipsoid ultrasound focus.

11. A method as claimed in claim 10 comprising composing said magnetic resonance image of adapted voxels having said longer side in a ratio to said primary axis of approximately 1:

3 or less.

12. A method as claimed in claim 10 comprising generating said magnetic resonance image as a slice image and forming said ultrasound focus in said slice image with a plurality of said adapted voxels in a range between six adapted voxels and nine adapted voxels.

13. A method as claimed in claim 10 comprising composing said magnetic resonance image of adapted voxels having a ratio between said longer side and said shorter side adapted in a range between 2:

1 and 5;

1.

14. A method as claimed in claim 13 comprising composing said magnetic resonance image of adapted voxels having a ratio between said longer side and said shorter side of approximately 3:

1.

15. A method as claimed in claim 9 comprising setting the cuboid shape of each of said adapted voxels to be the same for all of said adapted voxels.