Two-chamber cartridge for propellant-free metering aerosols
First Claim
1. A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation, comprising:
- an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container;
a cartridge chamber disposed at the lower end of the displacing device and operable to store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening;
a cannula guide extending from the upper end of the displacing device to the cartridge chamber;
a first pierceably sealed opening disposed between the cartridge chamber and the guide; and
a second pierceably sealed opening disposed between the cartridge chamber and the container, which is sealed with a sealing film including one or more frangible points between the sealing film and a periphery of the second opening such that when the first opening is pierced by pressure, the sealing film tears at the one or more frangible points,wherein insertion of a cannula through the guide pierces the first pierceably sealed opening causing the second pierceably sealed opening to open and releases pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.
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Accused Products
Abstract
A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation includes: an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; and a cannula guide extending from the upper end of the displacing device to the cartridge chamber, wherein insertion of a cannula through the guide pierces the sealed opening and releases the pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.
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Citations
10 Claims
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1. A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation, comprising:
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an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container; a cartridge chamber disposed at the lower end of the displacing device and operable to store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening; a cannula guide extending from the upper end of the displacing device to the cartridge chamber; a first pierceably sealed opening disposed between the cartridge chamber and the guide; and a second pierceably sealed opening disposed between the cartridge chamber and the container, which is sealed with a sealing film including one or more frangible points between the sealing film and a periphery of the second opening such that when the first opening is pierced by pressure, the sealing film tears at the one or more frangible points, wherein insertion of a cannula through the guide pierces the first pierceably sealed opening causing the second pierceably sealed opening to open and releases pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification