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Two-chamber cartridge for propellant-free metering aerosols

  • US 7,793,655 B2
  • Filed: 07/11/2005
  • Issued: 09/14/2010
  • Est. Priority Date: 04/19/1996
  • Status: Expired due to Fees
First Claim
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1. A cartridge for propellant-free administration of a liquid pharmaceutical composition by inhalation, comprising:

  • an elongate displacing device including an upper end and a lower end, the lower end for at least partial insertion into a container;

    a cartridge chamber disposed at the lower end of the displacing device and operable to store a pharmaceutical formulation, the cartridge chamber including at least one pierceably sealed opening;

    a cannula guide extending from the upper end of the displacing device to the cartridge chamber;

    a first pierceably sealed opening disposed between the cartridge chamber and the guide; and

    a second pierceably sealed opening disposed between the cartridge chamber and the container, which is sealed with a sealing film including one or more frangible points between the sealing film and a periphery of the second opening such that when the first opening is pierced by pressure, the sealing film tears at the one or more frangible points,wherein insertion of a cannula through the guide pierces the first pierceably sealed opening causing the second pierceably sealed opening to open and releases pharmaceutical formulation into a liquid solvent in the container to form the liquid pharmaceutical composition.

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