Bymixer apparatus and method for fast-response, adjustable measurement of mixed gas fractions in ventilation circuits

• US 7,793,659 B2
• Filed: 10/14/2003
• Issued: 09/14/2010
• Est. Priority Date: 10/11/2002
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Breen, Peter H.
• Primary Examiner(s): Yu; Justin R
• Assistant Examiner(s): DIXON, ANNETTE FREDRICKA
• Application Number:
  US10/530,602
• Publication Number:
  US 20060201503A1
• Time in Patent Office: 2,527 Days
• Field of Search: 128/200.24, 12820312-20418, 128/204.21
• US Class Current: 128/204.18
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: A61B 5/091 Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61M 16/01 specially adapted for anaesthetising A61M16/104, A61M16/18 take precedence
• CPC Class Codes: A61M 16/08 Bellows; Connecting tubes having means for taking samples G01N1/22; Water traps; Patient circuits
• CPC Class Codes: A61M 16/085 Gas sampling
• CPC Class Codes: A61M 16/0866 Passive resistors therefor
• CPC Class Codes: A61M 16/0875 Connecting tubes
• CPC Class Codes: A61M 16/0891 Closed circuit, e.g. for anaesthesia
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/22 Carbon dioxide-absorbing devices ; Other means for removing carbon dioxidecartridges with absorbing substances for respiratory apparatus A62B19/00
• CPC Class Codes: A61M 2016/003 with a flowmeter
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2230/43 Composition of exhalation
• CPC Class Codes: A61M 2230/432 partial CO2 pressure (P-CO2)
• CPC Class Codes: A61M 2230/435 partial O2 pressure (P-O2)
• CPC Class Codes: A61M 2230/437 the anaesthetic agent concentration
• CPC Class Codes: A61M 2230/50 Temperature

Abstract

A bymixer device and method which provides fast-response, accurate measurements of mixed inspired and/or expired gas fractions in open or closed ventilation circuits and/or in circle circuits used in anesthesia and/or critical care. The bymixer device may include a main flow channel and a bypass flow channel. The bypass flow channel includes a flow-restrictor (e.g, an orifice) that partially blocks the flow of respiratory gas through the bypass flow channel, a mixing chamber positioned upstream of the flow restrictor and a sampling apparatus (e.g., a port for withdrawing samples of gas from said mixing chamber and/or sensor(s) positioned within the mixing chamber).

Claims

1. A bymixer device comprising:

an inflow port connectable to a conduit such that all respiratory gas flowing through that conduit will enter the inflow port;

a flow divider which divides the flow of respiratory gas that enters the inflow port into first and second streams;

a main flow channel through which the first stream flows;

a bypass flow channel through which the second stream flows;

said bypass flow channel comprising a) a flow restrictor that restricts the flow of gas through the bypass flow channel, b) a mixing chamber positioned upstream of the flow restrictor, said mixing chamber comprising tubing that is alternately extendable and contractible so as to enable a user to alternately increase and decrease the volume of the mixing chamber; and

c) sampling apparatus for sampling respiratory gas from said mixing chamber;

a flow combiner that combines the first and second streams after they have passed through the main flow channel and bypass flow channel to form a combined outflow stream; and

an outflow port that is connectable to a conduit such that the combined outflow stream enters that conduit.

2. A bymixer device according to claim 1 wherein the flow restrictor is variable.

3. A bymixer device according to claim 1 wherein the main flow channel comprises a substantially rigid plastic tube.

4. A bymixer device according to claim 3 wherein the sampling apparatus is selected from the group consisting of:

a port through which a sample of gas may be removed from the mixing chamber; and

a sensor positioned so as to sample gas within the mixing chamber.

5. A system comprising a bymixer device according to claim 1 further in combination with a monitoring device that is connected to the sampling apparatus and useable to determine at least one variable in gas sampled from the mixing chamber.

6. A system according to claim 5 wherein the monitoring device comprises a device useable for performing capnography or calorimetry.

7. A system according to claim 5 wherein the monitoring device is operative to determine and/or compute at least one variable selected from the group consisting of:

average alveolar PCO₂

volume-averaged alveolar PCO₂ (PĒ

_CO2);

CO₂ elimination ({dot over (V)}_CO2);

pulmonary oxygen uptake ({dot over (V)}_O2)_;

concentration or partial pressure of volatile gases; and

concentration or partial pressure of non-volatile gasses.

8. A system according to claim 5 further comprising a display apparatus connected to or formed integrally of the monitoring device for displaying at least one variable determined by the monitoring device.

9. A system according to claim 5 further comprising computing apparatus for computing one or more calculated values using at least one variable determined by the monitoring device.

10. A system according to claim 9 wherein the computing apparatus is programmable.

11. A system according to claim 9 wherein the computing apparatus comprises a microprocessor.

12. A system according to claim 9 wherein the system receives data required for and is equipped to calculations one or more values selected from the group consisting of:

Minute Ventilation ({dot over (V)}E);

Tidal Volume (V_T);

Inspiratory Reserve Volume (IRV);

Expiratory Reserve Volume (ERV);

Total Lung Capacity (TLC);

Functional Residual Capacity (FRC);

Vital Capacity (VC);

Pulmonary Oxygen Uptake Per Breath (VO_2,br); and

Pulmonary Carbon Dioxide Elimination Per Breath (VCO_2,br).

13. A ventilation circuit for use in ventilating a human or veterinary patient, said ventilation circuit comprising:

a) an inspiratory flow conduit that carries a flow of inspiratory respiratory gas for delivery into the patient'"'"'s lungs;

b) an expiratory flow conduit for carrying expired respiratory gas that has been expelled from the patient'"'"'s lungs;

c) a first bymixer device connected to the inspiratory flow conduit such that samples of mixed inspiratory respiratory gas may be obtained from a sample port of the bymixer; and

d) a second bymixer device connected to the expiratory flow conduit such that samples of mixed expiratory respiratory gas may be obtained from a sample port of the bymixer;

wherein each of said first and second bymixer devices comprises;

i) a flow divider for dividing the flow of respiratory gas into first and second streams;

ii) a main flow channel through which the first stream flows;

iii) a bypass flow channel through which the second stream flows, said bypass flow channel comprising a flow restrictor that restricts the flow of gas through the bypass flow channel, a mixing chamber positioned upstream of the flow restrictor and sampling apparatus for sampling respiratory gas from said mixing chamber.

14. A ventilation circuit according to claim 13 wherein the ventilation circuit is an open circuit wherein expired respiratory gas is not recycled into the inspiratory flow conduit.

15. A ventilation circuit according to claim 13 wherein the ventilation circuit is a closed or circle circuit wherein expired respiratory gas is recycled into the inspiratory flow conduit.

16. A ventilation circuit according to claim 15 further comprising a carbon dioxide absorber for removing at least some carbon dioxide from the expired respiratory gas before it is recycled into the inspiratory flow conduit.

17. A ventilation circuit according to claim 15, further comprising a fresh gas inflow conduit for combining fresh respiratory gas with recycled expired respiratory gas such that the inspiratory flow conduit carries a mixture of fresh respiratory gas and recycled expired respiratory gas.

18. A ventilation circuit according to claim 13 wherein the bymixer is connected to the inspiratory flow conduit such that samples of mixed inspiratory respiratory gas may be obtained from the sample port of the bymixer.

19. A ventilation circuit according to claim 13 wherein the bymixer is connected to the expiratory flow conduit such that samples of mixed expiratory respiratory gas may be obtained from the sample port of the bymixer.

20. A ventilation circuit according to claim 13 further comprising a source of anesthetic gas such that inspiratory respiratory gas that flows through the inspiratory flow conduit includes at least one anesthetic gas.

21. A method for sampling mixed respiratory gas in a ventilation circuit for ventilating the lungs of a human or veterinary patient, said ventilation circuit including at least one inspiratory flow conduit through which inspiratory respiratory gas flows for delivery to the patient'"'"'s lungs and at least one expiratory flow conduit through which expired respiratory gas flows after having been expelled from the patient'"'"'s lungs, said method comprising the steps of:

A) providing a bymixer device which comprises i) an inflow port connectable to a conduit such that all respiratory gas flowing through that conduit will enter the inflow port;

ii) a flow divider which divides the flow of respiratory gas that enters the inflow port into first and second streams;

iii) a main flow channel through which the first stream flows;

iv) a bypass flow channel through which the second stream flows, said bypass flow channel comprising a flow restrictor that restricts the flow of gas through the bypass flow channel, v) a mixing chamber upstream of the flow restrictor, said mixing chamber comprising tubing that is alternately extendable and contractible to enable a used to alternately increase and decrease the volume of the mixing chamber;

vi) sampling apparatus for sampling respiratory gas from said mixing chamber;

vii) a flow combiner that combines the first and second streams after they have passed through the main flow channel and bypass flow channel to form a combined outflow stream; and

viii) an outflow port that is connectable to a conduit such that the combined outflow stream enters that conduit;

B) connecting the inflow port of the bimixer to a first respiratory gas flow conduit and the outflow port to a second respiratory gas flow conduit such that respiratory gas flows through the bypass channel and becomes mixed in the mixing chamber; and

C) using the sampling apparatus to sample mixed respiratory gas from mixing chamber.

22. A method according to claim 21 wherein Step C comprises withdrawing a sample from the mixing chamber.

23. A method according to claim 21 wherein Step C comprises positioning a sensor within the mixing chamber and measuring a component of the gas within the mixing chamber by way of said sensor.

24. A method according to claim 21 further comprising the step of:

D) determining at least one variable from mixed respiratory gas sampled in Step C.

25. A method according to claim 24 wherein Step D comprises performing capnography on mixed respiratory gas sampled in Step C.

26. A method according to claim 24 wherein Step D comprises performing calorimetry on mixed respiratory gas sampled in Step C.

27. A method according to claim 24 wherein Step D comprises determining and/or computing at least one variable selected from the group consisting of:

volume-averaged alveolar PCO₂ (PĒ

_CO2);

pulmonary carbon dioxide elimination ({dot over (V)}_CO2);

pulmonary oxygen uptake ({dot over (V)}_O2);

concentration or partial pressure of volatile gases; and

concentration or partial pressure of non-volatile gasses.

28. A method according to claim 21 further comprising the step of determining one or more values selected from the group consisting of:

minute ventilation ({dot over (V)}E);

tidal volume (V_T);

Total Lung Capacity (TLC);

Functional Residual Capacity (FRC);

Vital Capacity (VC);

pulmonary carbon dioxide elimination per breath ({dot over (V)}_CO2,br); and

Pulmonary Carbon Dioxide Elimination Per Breath (VCO_2,br).

29. A method according to claim 21 wherein the method further comprises the step of:

D) changing the size of the mixing chamber.

30. A method according to claim 21 wherein the degree of flow restriction caused by the flow restrictor is variable and wherein the method further comprises the step of:

D) varying the degree of flow restriction caused by the flow restrictor to change the flow rate of gas through the mixing chamber.

31. A method according to claim 21 wherein the first and second respiratory gas flow conduits comprise first and second portions of an inspiratory gas flow conduit.

32. A method according to claim 21 wherein the first and second respiratory gas flow conduits comprise first and second portions of an expiratory gas flow conduit.